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Transcriptional Regulation of Myelopoiesis

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Abstract

A common myeloid progenitor gives rise to both granulocytes and monocytes. The early stages of granulopoiesis are mediated by the C/EBPα, PU.1, RAR, CBF, and c-Myb transcription factors, and the later stages require C/EBPε, PU.1, and CDP. Monocyte development requires PU.1 and interferon consensus sequence binding protein and can be induced by Maf-B, c-Jun, or Egr-1. Cytokine receptor signals modulate transcription factor activities but do not determine cell fates. Several mechanisms orchestrate the myeloid developmental program, including cooperative gene regulation, protein:protein interactions, regulation of factor levels, and induction of cell cycle arrest.

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  1. Division of Pediatric Oncology, Johns Hopkins University, Cancer Research Building, Rm 253, 1650 Orleans St, Baltimore, 21231, Maryland, USA

    Alan D. Friedman

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Friedman, A.D. Transcriptional Regulation of Myelopoiesis. Int J Hematol 75, 466–472 (2002). https://doi.org/10.1007/BF02982108

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  • DOI: https://doi.org/10.1007/BF02982108

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