Acatalasemia in the mouse and other species
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- Feinstein, R.N. Biochem Genet (1970) 4: 135. doi:10.1007/BF00484026
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Genetic control of the level of blood catalase activity was first demonstrated in 1927. At present, such control has been demonstrated or suggested for nine different species, including man, the most studied. The development of an acatalasemic strain of mice has permitted a wide variety of experimental approaches, including most of those used in humans. Among those approaches which cannot readily be applied to man but have been used in acatalasemic mice are investigations of sensitivity to radiation lethality, mechanism of awareness to radiation, possible use as a model for replacement therapy for inborn errors of metabolism, and catalase in tissues other than erythrocytes. These are described, together with genetic, immunological, and other studies comparable to similar work on acatalasemic humans.