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Effect of screening mammography on cumulative survival of Japanese women aged 40–69 years with breast cancer

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Abstract

Background

The effectiveness of screening mammography (MMG) has mainly been demonstrated by studies in western countries. This study was conducted to evaluate cumulative survival and the risk of breast cancer death among Japanese women aged 40–69 years with screening-detected and interval breast cancer divided into three groups: MMG with clinical breast examination (CBE), CBE alone, and self-detection.

Methods

By matching a list of 126,537 women (358,242 person-screenings) who participated in the Miyagi Cancer Society Screening program between 1 April 1995 and 31 December 2002 with the Miyagi Prefectural Cancer Registry, 429 MMG with CBE, 522 CBE, and 3,047 self-detected cases were included in this study. Follow-up was performed until the date of death or 31 December 2007. Survival was estimated by the Kaplan–Meier method. The Cox proportional hazards model was used to estimate hazard ratios (HR) and 95 % confidence intervals (CI) for breast cancer death.

Results

Five-year survival for women in the MMG with CBE, CBE, and self-detection groups was 96.8, 92.7, and 86.6 %, respectively. The HR (95 % CI) for breast cancer death was 2.38 (0.72–7.94) among CBE-screened and 4.44 (1.42–13.89) among self-detected cases for women aged 40–49 years, but was 3.00 (1.63–5.50) among CBE-screened and 4.51 (2.69–7.56) among self-detected cases for women aged 50–69 years relative to cases screened by use of MMG with CBE.

Conclusions

In terms of the survival and risk of breast cancer death, MMG with CBE may be more effective than MMG alone or self-detection for Japanese women aged 40–69 years.

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Acknowledgments

This work was supported by KAKENHI, including Grant-in-Aid for Scientific Research (C) (24590781), Grant-in-Aid for Young Scientists (A) (24689032), and the 3rd Term Comprehensive Control Research for Cancer (H23-Sanjigan-shitei-002) from the Ministry of Health, Labour and Welfare, Japan.

Conflict of interest

The authors have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Surgical Oncology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan

    Masaaki Kawai, Akihiko Suzuki, Takanori Ishida, Masakazu Amari & Noriaki Ohuchi

  2. Division of Epidemiology, Miyagi Cancer Center Research Institute, 47-1 Nodayama, Medeshima-Shiode, Natori, Miyagi, 981-1293, Japan

    Yoshikazu Nishino

  3. Division of Breast Surgery, Iwate Prefectural Central Hospital, 1-4-1 Ueda, Morioka, Iwate, 020-0066, Japan

    Koji Ohnuki

  4. Miyagi Cancer Society, 5-7-30 Kamisugi, Aoba-ku, Sendai, Miyagi, 980-0011, Japan

    Daisuke Shibuya

Authors
  1. Masaaki Kawai
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  2. Akihiko Suzuki
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  3. Yoshikazu Nishino
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  4. Koji Ohnuki
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  5. Takanori Ishida
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  6. Masakazu Amari
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  7. Daisuke Shibuya
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  8. Noriaki Ohuchi
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Corresponding author

Correspondence to Noriaki Ohuchi.

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Kawai, M., Suzuki, A., Nishino, Y. et al. Effect of screening mammography on cumulative survival of Japanese women aged 40–69 years with breast cancer. Breast Cancer 21, 542–549 (2014). https://doi.org/10.1007/s12282-012-0434-2

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  • DOI: https://doi.org/10.1007/s12282-012-0434-2

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