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Synthesis of optically active macrolides with hydrazide fragments from tetrahydropyran and L-(+)-tartaric acid derivatives

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Chemistry of Natural Compounds Aims and scope

The synthesis of two potentially useful optically active 23- and 30-membered macrolides containing a 1,2-diol system and dihydrazide fragments was developed starting from tetrahydropyran. It was based on [1+1]-condensation of 7-oxooctyl-7-oxooctanoate and bis(7-oxooctyl)hexanedioate with L-(+)-tartaric acid hydrazide.

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Correspondence to G. Yu. Ishmuratov.

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Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2013, pp. 592–594.

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Ishmuratov, G.Y., Yakovleva, M.P., Mingaleeva, G.R. et al. Synthesis of optically active macrolides with hydrazide fragments from tetrahydropyran and L-(+)-tartaric acid derivatives. Chem Nat Compd 49, 691–693 (2013). https://doi.org/10.1007/s10600-013-0708-8

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  • DOI: https://doi.org/10.1007/s10600-013-0708-8

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