Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study
Low serum 25-hydroxyvitamin D [25(OH)D] concentration may increase risk of insulin-requiring diabetes.
A nested case–control study was performed using serum collected during 2002–2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (±2 days), age (±3 months), length of service (±30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression.
ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (p trend <0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were <43 (median 28), 43–59 (median 52), 60–77 (median 70), 78–99 (median 88) and ≥100 (median 128).
Individuals with lower serum 25(OH)D concentrations had higher risk of insulin-requiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25(OH)D concentration ≥60 nmol/l.
- Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study
Volume 55, Issue 12 , pp 3224-3227
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- 25-Hydroxyvitamin D
- Insulin-requiring diabetes
- Military populations
- Nested case–control study
- Type 1 diabetes mellitus
- Industry Sectors
- Author Affiliations
- 1. Naval Health Research Center, 140 Sylvester Road, San Diego, CA, 92106-3521, USA
- 2. Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA
- 3. Division of Internal Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA
- 4. Miami Diabetes Research Institute, Department of Surgery and Cell Transplant Center, University of Miami Miller School of Medicine, Hollywood, FL, USA