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The Role of Aurora B Kinase in Normal and Cancer Cells

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Abstract

Aurora kinases are essential players in mammalian cell division. These kinases are involved in the regulation of spindle dynamics, microtubule–kinetochore interactions, and chromosome condensation and orientation during mitosis. At least three members of the Aurora family – Aurora kinases A, B, and C – have been identified in mammals. Aurora B is essential for maintaining genomic stability and normal cell division. Mutations and dysregulation of this kinase are implicated in tumor initiation and progression. In this review, we discuss the functions of Aurora B, the relationship between increased Aurora B activity and carcinogenesis, and the prospects for the use of Aurora B kinase inhibitors in antitumor therapy.

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Abbreviations

CPC:

chromosomal passenger complex

INCENP:

inner centromere protein

SAC:

spindle assembly checkpoint

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Funding

The work was supported by the Russian Science Foundation (project 23-15-00433).

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Authors and Affiliations

  1. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia

    Ekaterina Titova, Galina Shagieva & Vera Dugina

  2. Faculty of Biology, Lomonosov Moscow State University, 119991, Moscow, Russia

    Vera Dugina

  3. Institute of Carcinogenesis, Blokhin National Medical Research Centre of Oncology, Ministry of Health of the Russian Federation, 115478, Moscow, Russia

    Pavel Kopnin

Authors
  1. Ekaterina Titova
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  2. Galina Shagieva
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  3. Vera Dugina
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  4. Pavel Kopnin
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Contributions

V.D. conceived and supervised the study; E.T. and G.Sh. wrote the manuscript; G.Sh. and P.K. edited the manuscript.

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Correspondence to Ekaterina Titova.

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Titova, E., Shagieva, G., Dugina, V. et al. The Role of Aurora B Kinase in Normal and Cancer Cells. Biochemistry Moscow 88, 2054–2062 (2023). https://doi.org/10.1134/S0006297923120088

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  • DOI: https://doi.org/10.1134/S0006297923120088

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