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Benign Paranasal Sinus Tumors

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Abstract

Purpose of Review

Although common, benign tumors in the nasal cavity and paranasal sinuses are often challenging to diagnose as they encompass a broad spectrum with many tumor types. The clinical symptoms and signs associated with tumors in this region are often vague and non-specific and could be mistaken for malignant tumors. This study aims to review the current knowledge on the tumors of the nasal and paranasal sinuses and their clinical presentation.

Recent Findings

Most benign tumors have imaging and pathological features, which combined with the patient’s history and demographic, can help differentiate them from other tumors in the same region.

Summary

This article summarizes the clinical, pathologic, and imaging features of benign tumors in the nasal and paranasal sinuses and their differential diagnoses. Further investigation into these entities may help streamline the diagnostic procedure, protect patients from anxiety, and ensure timely diagnosis and treatment.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Shirazi N, Bist SS, Selvi TN, Harsh M. Spectrum of sinonasal tumors: a 10-year experience at a tertiary care hospital in North India. Oman Med J. 2015;30(6):435–40. https://doi.org/10.5001/omj.2015.86.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Garg D, Mathur K. Clinico-pathological study of space occupying lesions of nasal cavity, paranasal sinuses and nasopharynx. J Clin Diagn Res. 2014;8(11):FC04–7. https://doi.org/10.7860/JCDR/2014/10662.5150.

  3. Mk A, Gm V, Sa A, Vr R. Histopathological study of lesions of nose and paranasal sinuses. Indian J Otolaryngol Head Neck Surg. 2012;64(3):275–9. https://doi.org/10.1007/s12070-011-0286-7.

    Article  Google Scholar 

  4. Khandekar S, Dive A, Mishra R, Upadhyaya N. Sinonasal inverted papilloma: a case report and mini review of histopathological features. J Oral Maxillofac Pathol Sep-Dec. 2015;19(3):405. https://doi.org/10.4103/0973-029X.174644.

    Article  Google Scholar 

  5. Mehrad M, Stelow EB, Bishop JA, et al. Transcriptionally active HPV and targetable EGFR mutations in sinonasal inverted papilloma: an association between low-risk HPV, condylomatous morphology, and cancer risk? Am J Surg Pathol. 2020;44(3):340–6. https://doi.org/10.1097/PAS.0000000000001411.

    Article  PubMed  Google Scholar 

  6. Lawson W, Patel ZM. The evolution of management for inverted papilloma: an analysis of 200 cases. Otolaryngol Head Neck Surg. 2009;140(3):330–5. https://doi.org/10.1016/j.otohns.2008.11.010.

    Article  PubMed  Google Scholar 

  7. •• Tatekawa H, Shimono T, Ohsawa M, Doishita S, Sakamoto S, Miki Y. Imaging features of benign mass lesions in the nasal cavity and paranasal sinuses according to the 2017 WHO classification. Jpn J Radiol. 2018;36(6):361–81. https://doi.org/10.1007/s11604-018-0739-y. This article provided a comprehensive overview of imaging features of benign mass lesions in the nasal cavity and paranasal sinuses.

    Article  CAS  PubMed  Google Scholar 

  8. •• Thompson LDR, Bishop JA. Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: nasal cavity, paranasal sinuses and skull base. Head Neck Pathol. 2022;16(1):1–18. https://doi.org/10.1007/s12105-021-01406-5. This article discussed important updates in the World Health Organization Classification of Head and Neck Tumors and provided snapshot of important entities, including both malignant and benign tumors.

  9. de Saint HT, Rumeau C, Gallet P, Nguyen-Thi PL, Jankowski R, Nguyen DT. Difference between respiratory epithelial adenomatoid hamartomas and small malignant tumours of the olfactory cleft on CT scans in forty-six patients. Clin Otolaryngol. 2017;42(6):1421–5. https://doi.org/10.1111/coa.12930.

    Article  Google Scholar 

  10. Wenig BM, Heffner DK. Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases. Ann Otol Rhinol Laryngol. 1995;104(8):639–45. https://doi.org/10.1177/000348949510400809.

    Article  CAS  PubMed  Google Scholar 

  11. Nguyen DT, Gauchotte G, Arous F, Vignaud JM, Jankowski R. Respiratory epithelial adenomatoid hamartoma of the nose: an updated review. Am J Rhinol Allergy Sep-Oct. 2014;28(5):187–92. https://doi.org/10.2500/ajra.2014.28.4085.

    Article  Google Scholar 

  12. Vira D, Bhuta S, Wang MB. Respiratory epithelial adenomatoid hamartomas. Laryngoscope. 2011;121(12):2706–9. https://doi.org/10.1002/lary.22399.

    Article  PubMed  Google Scholar 

  13. Delbrouck C, Fernandez Aguilar S, Choufani G, Hassid S. Respiratory epithelial adenomatoid hamartoma associated with nasal polyposis. Am J Otolaryngol Jul-Aug. 2004;25(4):282–4. https://doi.org/10.1016/j.amjoto.2004.02.005.

    Article  Google Scholar 

  14. Hawley KA, Pabon S, Hoschar AP, Sindwani R. The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH). Int Forum Allergy Rhinol. 2013;3(3):248–53. https://doi.org/10.1002/alr.21083.

    Article  PubMed  Google Scholar 

  15. Safi C, Li C, Tabaee A, Ramakrishna R, Riley CA. Outcomes and imaging findings of respiratory epithelial adenomatoid hamartoma: a systematic review. Int Forum Allergy Rhinol. 2019;9(6):674–80. https://doi.org/10.1002/alr.22298.

    Article  PubMed  Google Scholar 

  16. Sangoi AR, Berry G. Respiratory epithelial adenomatoid hamartoma: diagnostic pitfalls with emphasis on differential diagnosis. Adv Anat Pathol. 2007;14(1):11–6. https://doi.org/10.1097/PAP.0b013e31802efb1e.

    Article  PubMed  Google Scholar 

  17. Lima NB, Jankowski R, Georgel T, Grignon B, Guillemin F, Vignaud JM. Respiratory adenomatoid hamartoma must be suspected on CT-scan enlargement of the olfactory clefts. Rhinology. 2006;44(4):264–9.

    PubMed  Google Scholar 

  18. Hawley KA, Ahmed M, Sindwani R. CT findings of sinonasal respiratory epithelial adenomatoid hamartoma: a closer look at the olfactory clefts. AJNR Am J Neuroradiol. 2013;34(5):1086–90. https://doi.org/10.3174/ajnr.A3345.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Davison WL, Pearlman AN, Donatelli LA, Conley LM. Respiratory epithelial adenomatoid hamartomas: an increasingly common diagnosis in the setting of nasal polyps. Am J Rhinol Allergy. 2016;30(4):139–46. https://doi.org/10.2500/ajra.2016.30.4338.

    Article  PubMed  Google Scholar 

  20. Kumar D, Handa KK, Handa A, Gautam P. Recurrent respiratory epithelial adenomatoid hamartoma of the nasal cavity. Proc (Bayl Univ Med Cent). 2022;35(5):668–9. https://doi.org/10.1080/08998280.2022.2086783.

    Article  PubMed  Google Scholar 

  21. Huang YW, Kuo YJ, Ho CY, Lan MY. Sinonasal seromucinous hamartoma. Eur Arch Otorhinolaryngol. 2018;275(3):743–9. https://doi.org/10.1007/s00405-018-4885-8.

    Article  PubMed  Google Scholar 

  22. Tong KN, Serra RM, Shih RY, Foss RD. Seromucinous hamartoma of the nasal cavity. Head Neck Pathol. 2019;13(2):239–42. https://doi.org/10.1007/s12105-018-0914-6.

    Article  PubMed  Google Scholar 

  23. Lee DH, Yoon TM, Lee JK, Lim SC. Seromucinous hamartoma of inferior turbinate: a case report. Medicine (Baltimore). 2018;97(45):e13022. https://doi.org/10.1097/MD.0000000000013022.

  24. Li R, Saluja K, Lin M, Hu Z, Cai Z, Zhu H. Sinonasal hamartomas: from nasal chondromesenchymal hamartoma to respiratory epithelial adenomatoid hamartoma. Report of six Cases and Review of the Literature. Int J Surg Pathol. 2022;30(4):448–456. https://doi.org/10.1177/10668969211064211.

  25. Rengifo DA, Varadarajan VV, Lai J, Justice JM. Transformation from sinonasal seromucinous hamartoma to adenocarcinoma: a case report. ORL J Otorhinolaryngol Relat Spec. 2021;83(6):478–80. https://doi.org/10.1159/000514641.

    Article  PubMed  Google Scholar 

  26. Mason KA, Navaratnam A, Theodorakopoulou E, Chokkalingam PG. Nasal chondromesenchymal hamartoma (NCMH): a systematic review of the literature with a new case report. J Otolaryngol Head Neck Surg. 2015;44:28. https://doi.org/10.1186/s40463-015-0077-3.

  27. Javadirad E, Azimivaghar J, Montazer S, Sharafi S. A systematic review of nasal chondromesenchymal hamartoma (NCMH) with a new case report. Head Neck Pathol. 2022. https://doi.org/10.1007/s12105-022-01452-7.

  28. Schultz KAP, Stewart DR, Kamihara J, et al. DICER1 tumor predisposition. In: Adam MP, Everman DB, Mirzaa GM, et al, eds. GeneReviews((R)). 1993.

  29. Yao-Lee A, Ryan M, Rajaram V. Nasal chondromesenchymal hamartoma: correlation of typical MR. CT and pathological findings Pediatr Radiol. 2011;41(5):675–7. https://doi.org/10.1007/s00247-011-2034-2.

    Article  PubMed  Google Scholar 

  30. Johnson C, Nagaraj U, Esguerra J, Wasdahl D, Wurzbach D. Nasal chondromesenchymal hamartoma: radiographic and histopathologic analysis of a rare pediatric tumor. Pediatr Radiol. 2007;37(1):101–4. https://doi.org/10.1007/s00247-006-0352-6.

    Article  PubMed  Google Scholar 

  31. Kim B, Park SH, Min HS, Rhee JS, Wang KC. Nasal chondromesenchymal hamartoma of infancy clinically mimicking meningoencephalocele. Pediatr Neurosurg May-Jun. 2004;40(3):136–40. https://doi.org/10.1159/000079857.

    Article  CAS  Google Scholar 

  32. Li Y, Yang QX, Tian XT, Li B, Li Z. Malignant transformation of nasal chondromesenchymal hamartoma in adult: a case report and review of the literature. Histol Histopathol. 2013;28(3):337–44. https://doi.org/10.14670/HH-28.337.

    Article  PubMed  Google Scholar 

  33. Weindorf SC, Brown NA, McHugh JB, Udager AM. Sinonasal papillomas and carcinomas: a contemporary update with review of an emerging molecular classification. Arch Pathol Lab Med. 2019;143(11):1304–16. https://doi.org/10.5858/arpa.2019-0372-RA.

    Article  CAS  PubMed  Google Scholar 

  34. Neel HB, 3rd, Whicker JH, Devine KD, Weiland LH. Juvenile angiofibroma. Review of 120 cases. Am J Surg. 1973;126(4):547–56. https://doi.org/10.1016/s0002-9610(73)80048-0.

  35. Schiff M. Juvenile nasopharyngeal angiofibroma. A theory of pathogenesis. Trans Am Laryngol Rhinol Otol Soc. 1959;1959:791–826.

  36. Schick B, Veldung B, Wemmert S, et al. p53 and Her-2/neu in juvenile angiofibromas. Oncol Rep. 2005;13(3):453–7.

    CAS  PubMed  Google Scholar 

  37. Li W, Ni Y, Lu H, Hu L, Wang D. Current perspectives on the origin theory of juvenile nasopharyngeal angiofibroma. Discov Med. 2019;27(150):245–54.

    PubMed  Google Scholar 

  38. Zhang PJ, Weber R, Liang HH, Pasha TL, LiVolsi VA. Growth factors and receptors in juvenile nasopharyngeal angiofibroma and nasal polyps: an immunohistochemical study. Arch Pathol Lab Med. 2003;127(11):1480–4. https://doi.org/10.5858/2003-127-1480-GFARIJ.

    Article  CAS  PubMed  Google Scholar 

  39. Tork CA, Simpson DL. Nasopharyngeal angiofibroma. StatPearls. 2022.

  40. Yin Z, Wang Y, Wu Y, et al. Age distribution and age-related outcomes of olfactory neuroblastoma: a population-based analysis. Cancer Manag Res. 2018;10:1359–64. https://doi.org/10.2147/CMAR.S151945.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Su ZY, Siak PY, Leong CO, Cheah SC. The role of Epstein-Barr virus in nasopharyngeal carcinoma. Front Microbiol. 2023;14:1116143. https://doi.org/10.3389/fmicb.2023.1116143.

    Article  PubMed  PubMed Central  Google Scholar 

  42. • Fernandez KS, de Alarcon A, Adams DM, Hammill AM. Sirolimus for the treatment of juvenile nasopharyngeal angiofibroma. Pediatr Blood Cancer. 2020;67(4):e28162. https://doi.org/10.1002/pbc.28162. This article described promising results of sirolimus as an alternative to endoscopic treatment of juvenile nasopharyngeal angiofibroma, prompting larger scale study to assess long-term efficacy of the treatment option for this invasive disease.

  43. McCombe A, Lund VJ, Howard DJ. Recurrence in juvenile angiofibroma. Rhinology. 1990;28(2):97–102.

    CAS  PubMed  Google Scholar 

  44. Allensworth JJ, Troob SH, Lanciault C, Andersen PE. High-grade malignant transformation of a radiation-naive nasopharyngeal angiofibroma. Head Neck. 2016;38(Suppl 1):E2425–7. https://doi.org/10.1002/hed.24378.

    Article  PubMed  Google Scholar 

  45. Mohebbi S, Aghajanpour M. From juvenile nasopharyngeal angiofibroma to nasopharyngeal carcinoma; a rare case report of nasopharyngeal mass. Bull Emerg Trauma. 2019;7(4):424–6. https://doi.org/10.29252/beat-070414.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Obeidin F, Jennings LJ, Alexiev BA. Sinonasal glomangiopericytoma: a clinicopathologic study. Pathol Res Pract. 2019;215(5):983–7. https://doi.org/10.1016/j.prp.2019.02.004.

    Article  PubMed  Google Scholar 

  47. Jo VY, Fletcher CDM. Nuclear beta-catenin expression is frequent in sinonasal hemangiopericytoma and its mimics. Head Neck Pathol. 2017;11(2):119–23. https://doi.org/10.1007/s12105-016-0737-2.

    Article  PubMed  Google Scholar 

  48. Haller F, Bieg M, Moskalev EA, et al. Recurrent mutations within the amino-terminal region of beta-catenin are probable key molecular driver events in sinonasal hemangiopericytoma. Am J Pathol. 2015;185(2):563–71. https://doi.org/10.1016/j.ajpath.2014.10.019.

    Article  CAS  PubMed  Google Scholar 

  49. Thompson LD, Miettinen M, Wenig BM. Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. Am J Surg Pathol. 2003;27(6):737–49. https://doi.org/10.1097/00000478-200306000-00004.

    Article  PubMed  Google Scholar 

  50. Neha B, Shashi D, Seema R. Spindle cell squamous cell carcinoma of head and neck region: a clinicopathological and immunohistochemical study. Indian J Surg Oncol. 2021;12(4):699–705. https://doi.org/10.1007/s13193-021-01418-1.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Mentzel T, Dry S, Katenkamp D, Fletcher CD. Low-grade myofibroblastic sarcoma: analysis of 18 cases in the spectrum of myofibroblastic tumors. Am J Surg Pathol. 1998;22(10):1228–38. https://doi.org/10.1097/00000478-199810000-00008.

    Article  CAS  PubMed  Google Scholar 

  52. Suh CH, Lee JH, Lee MK, et al. CT and MRI findings of glomangiopericytoma in the head and neck: case series study and systematic review. AJNR Am J Neuroradiol. 2020;41(1):155–9. https://doi.org/10.3174/ajnr.A6336.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Yang BT, Song ZL, Wang YZ, Dong JY, Wang ZC. Solitary fibrous tumor of the sinonasal cavity: CT and MR imaging findings. AJNR Am J Neuroradiol Jun-Jul. 2013;34(6):1248–51. https://doi.org/10.3174/ajnr.A3485.

    Article  CAS  Google Scholar 

  54. Schafer DR, Thompson LD, Smith BC, Wenig BM. Primary ameloblastoma of the sinonasal tract: a clinicopathologic study of 24 cases. Cancer. 1998;82(4):667–74. https://doi.org/10.1002/(sici)1097-0142(19980215)82:4%3c667::aid-cncr8%3e3.0.co;2-i.

    Article  CAS  PubMed  Google Scholar 

  55. Barrena BG, Phillips BJ, Moran KJ, Betz SJ. Sinonasal ameloblastoma. Head Neck Pathol. 2019;13(2):247–50. https://doi.org/10.1007/s12105-018-0933-3.

    Article  PubMed  Google Scholar 

  56. Muller HL, Merchant TE, Warmuth-Metz M, Martinez-Barbera JP, Puget S. Craniopharyngioma. Nat Rev Dis Primers. 2019;5(1):75. https://doi.org/10.1038/s41572-019-0125-9.

  57. Capatina C, Vintila M, Gherlan I, et al. Craniopharyngioma - clinical and therapeutic outcome data in a mixed cohort of adult and paediatric cases. Acta Endocrinol (Buchar). 2018;14(4):549–555. https://doi.org/10.4183/aeb.2018.549.

  58. Yoshimoto K, Hatae R, Suzuki SO, et al. High-resolution melting and immunohistochemical analysis efficiently detects mutually exclusive genetic alterations of adamantinomatous and papillary craniopharyngiomas. Neuropathology. 2018;38(1):3–10. https://doi.org/10.1111/neup.12408.

    Article  CAS  PubMed  Google Scholar 

  59. Gao C, Wang Y, Broaddus R, Sun L, Xue F, Zhang W. Exon 3 mutations of CTNNB1 drive tumorigenesis: a review. Oncotarget. 2018;9(4):5492–508. https://doi.org/10.18632/oncotarget.23695.

    Article  PubMed  Google Scholar 

  60. Johnson LN, Hepler RS, Yee RD, Frazee JG, Simons KB. Magnetic resonance imaging of craniopharyngioma. Am J Ophthalmol. 1986;102(2):242–4. https://doi.org/10.1016/0002-9394(86)90152-2.

    Article  CAS  PubMed  Google Scholar 

  61. Jastania RA, Saeed M, Al-Khalidi H, et al. Adamantinomatous craniopharyngioma in an adult: a case report with NGS analysis. Int Med Case Rep J. 2020;13:123–37. https://doi.org/10.2147/IMCRJ.S243405.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Fjalldal S, Follin C, Gabery S, et al. Detailed assessment of hypothalamic damage in craniopharyngioma patients with obesity. Int J Obes (Lond). 2019;43(3):533–44. https://doi.org/10.1038/s41366-018-0185-z.

    Article  CAS  PubMed  Google Scholar 

  63. Ishida M, Hotta M, Tsukamura A, et al. Malignant transformation in craniopharyngioma after radiation therapy: a case report and review of the literature. Clin Neuropathol Jan-Feb. 2010;29(1):2–8. https://doi.org/10.5414/npp29002.

    Article  CAS  Google Scholar 

  64. Abir M, Rihab L, Bellakhdhar M, et al. A rare case of primary sinonasal meningioma: a case report. Int J Surg Case Rep. 2022;99:107620. https://doi.org/10.1016/j.ijscr.2022.107620.

  65. Maharjan L, Neupane Y, Pradhan B. Primary atypical meningioma of the nasal cavity: a case report and review of the literature. Case Rep Otolaryngol. 2018;2018:7541892. https://doi.org/10.1155/2018/7541892.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Rushing EJ, Bouffard JP, McCall S, et al. Primary extracranial meningiomas: an analysis of 146 cases. Head Neck Pathol. 2009;3(2):116–30. https://doi.org/10.1007/s12105-009-0118-1.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Possanzini P, Pipolo C, Romagnoli S, et al. Primary extra-cranial meningioma of head and neck: clinical, histopathological and immunohistochemical study of three cases. Acta Otorhinolaryngol Ital. 2012;32(5):336–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  68. Wu W, Zhou Y, Wang Y, et al. Clinical significance of somatostatin receptor (SSTR) 2 in meningioma. Front Oncol. 2020;10:1633. https://doi.org/10.3389/fonc.2020.01633.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Mnejja M, Hammami B, Bougacha L, et al. Primary sinonasal meningioma. Eur Ann Otorhinolaryngol Head Neck Dis. 2012;129(1):47–50. https://doi.org/10.1016/j.anorl.2011.01.008.

    Article  CAS  PubMed  Google Scholar 

  70. Mirian C, Duun-Henriksen AK, Juratli T, et al. Poor prognosis associated with TERT gene alterations in meningioma is independent of the WHO classification: an individual patient data meta-analysis. J Neurol Neurosurg Psychiatry. 2020;91(4):378–87. https://doi.org/10.1136/jnnp-2019-322257.

    Article  PubMed  Google Scholar 

  71. Juratli TA, Thiede C, Koerner MVA, et al. Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas. Oncotarget. 2017;8(65):109228–37. https://doi.org/10.18632/oncotarget.22650.

    Article  PubMed  PubMed Central  Google Scholar 

  72. D'Aguanno V, Ralli M, De Vincentiis L, et al. Sinonasal angioleiomyoma with adipocyte differentiation: clinicopathologic study of 2 cases and review of the literature. Ear Nose Throat J. 2021;100(5):NP222-NP224. https://doi.org/10.1177/0145561319878302.

  73. Zhu G, Xiao D, Sun P. Expression of estrogen and progesterone receptors in angioleiomyoma of the nasal cavity of six patients. Oncol Lett. 2016;11(4):2359–64. https://doi.org/10.3892/ol.2016.4230.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Whaley RD, Thompson LDR. Epstein-Barr virus-associated smooth muscle tumors of larynx: a clinicopathologic study and comprehensive literature review of 12 cases. Head Neck Pathol. 2021;15(4):1162–71. https://doi.org/10.1007/s12105-021-01328-2.

    Article  PubMed  PubMed Central  Google Scholar 

  75. Agaimy A, Michal M, Thompson LD, Michal M. Angioleiomyoma of the sinonasal tract: analysis of 16 cases and review of the literature. Head Neck Pathol. 2015;9(4):463–73. https://doi.org/10.1007/s12105-015-0636-y.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Delbrouck C, Chamiec M, Hassid S, Ghanooni R. Lobular capillary haemangioma of the nasal cavity during pregnancy. J Laryngol Otol. 2011;125(9):973–7. https://doi.org/10.1017/S0022215111001654.

    Article  CAS  PubMed  Google Scholar 

  77. Kinzinger MR, Strong EB, Bernard J, Steele TO. Intralesional bevacizumab for the treatment of recurrent sinonasal hemangioma. Ann Otol Rhinol Laryngol. 2018;127(12):969–73. https://doi.org/10.1177/0003489418802288.

    Article  PubMed  Google Scholar 

  78. Pasic TR, Makielski K. Nasal schwannoma. Otolaryngol Head Neck Surg. 1990;103(6):943–6. https://doi.org/10.1177/019459989010300610.

    Article  CAS  PubMed  Google Scholar 

  79. Magro G, Broggi G, Angelico G, et al. Practical approach to histological diagnosis of peripheral nerve sheath tumors: an update. Diagnostics (Basel). 2022;12(6). https://doi.org/10.3390/diagnostics12061463.

  80. Hasegawa SL, Mentzel T, Fletcher CD. Schwannomas of the sinonasal tract and nasopharynx. Mod Pathol. 1997;10(8):777–84.

    CAS  PubMed  Google Scholar 

  81. Gencarelli J, Rourke R, Ross T, et al. Atypical presentation of sinonasal cellular schwannoma: a nonsolitary mass with osseous, orbital, and intracranial invasion. J Neurol Surg Rep. 2014;75(1):e144–8. https://doi.org/10.1055/s-0034-1376424.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Aksakal C, Beyhan M, Gokce E. Evaluation of the association between paranasal sinus osteomas and anatomic variations using computed tomography. Turk Arch Otorhinolaryngol. 2021;59(1):54–64. https://doi.org/10.4274/tao.2020.5811.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Xu B, Mneimneh W, Torrence DE, et al. Misinterpreted myoepithelial carcinoma of salivary gland: a challenging and potentially significant pitfall. Am J Surg Pathol. 2019;43(5):601–9. https://doi.org/10.1097/PAS.0000000000001218.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Wang Q, Chen H, Wang S. Basal cell adenoma of nasal septum: report of a case and review of literature. Int J Clin Exp Pathol. 2015;8(2):2176–9.

    PubMed  PubMed Central  Google Scholar 

  85. Yang BT, Chong VF, Wang ZC, Xian JF, Chen QH. Sphenoid sinus ectopic pituitary adenomas: CT and MRI findings. Br J Radiol. 2010;83(987):218–24. https://doi.org/10.1259/bjr/76663418.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Aquila G, Alaimo A, Marracino L, et al. Characterization of the Notch pathway in nasal polyps of patients with chronic rhinosinusitis: a pilot study. Physiol Rep. 2022;10(16):e15403. https://doi.org/10.14814/phy2.15403.

  87. Mossa-Basha M, Ilica AT, Maluf F, Karakoc O, Izbudak I, Aygun N. The many faces of fungal disease of the paranasal sinuses: CT and MRI findings. Diagn Interv Radiol. 2013;19(3):195–200. https://doi.org/10.5152/dir.2012.003.

    Article  Google Scholar 

  88. Sasaki T, Takahashi K, Mineta M, Fujita T, Aburano T. Immunoglobulin G4-related sclerosing disease mimicking invasive tumor in the nasal cavity and paranasal sinuses. AJNR Am J Neuroradiol. 2012;33(2):E19-20. https://doi.org/10.3174/ajnr.A2495.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Nishino T, Toki F, Oyama H, Shimizu K, Shiratori K. Long-term outcome of autoimmune pancreatitis after oral prednisolone therapy. Intern Med. 2006;45(8):497–501. https://doi.org/10.2169/internalmedicine.45.1565.

    Article  PubMed  Google Scholar 

  90. Khosroshahi A, Bloch DB, Deshpande V, Stone JH. Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic disease. Arthritis Rheum. 2010;62(6):1755–62. https://doi.org/10.1002/art.27435.

    Article  CAS  PubMed  Google Scholar 

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Luong, T.T., Yan, C.H. Benign Paranasal Sinus Tumors. Curr Otorhinolaryngol Rep 11, 332–343 (2023). https://doi.org/10.1007/s40136-023-00466-1

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