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A variant of KSHV-associated inflammatory cytokine syndrome in elderly men of Mediterranean descent

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Abstract

The spectrum of HHV-8-associated disorders includes Kaposi’s sarcoma, primary effusion lymphoma, multicentric Castleman’s disease, and the recently described KSHV inflammatory cytokine syndrome (KICS), a life-threatening disorder complicating HIV infection. There have been no reports in the literature concerning non-immunosuppressed individuals affected with KICS. We report here a KICS-like illness occurring in two elderly Greek men without HIV infection or other recognizable cause of immunosuppression.

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Acknowledgements

We are indebted to Prof. P. Skendros (University of Thrace, Alexandroupolis, Greece) and to Dr. P. Kolovos (University Hospital of Alexandroupolis, Alexandroupolis, Greece) for offering useful comments on the manuscript.

Funding

We declare no funding for this article from any funding agency in the public, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece

    Konstantinos Liapis & Ioannis Kotsianidis

  2. Department of Hematology, Evangelismos Hospital, Athens, Greece

    Maria Bouzani

  3. Department of Infectious Diseases, Second University Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 681 00, Alexandroupolis, Greece

    Vasileios Petrakis

  4. Division of General Internal Medicine, Georgios Gennimatas Hospital, Athens, Greece

    Nikolaos I. Anagnostopoulos

Authors
  1. Konstantinos Liapis
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  2. Maria Bouzani
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  3. Vasileios Petrakis
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  4. Nikolaos I. Anagnostopoulos
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  5. Ioannis Kotsianidis
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Contributions

All authors were involved in the diagnosis and care of the patients. All authors have contributed to the writing of the manuscript and review of the literature. All authors reviewed and approved the final version of the manuscript.

Corresponding author

Correspondence to Vasileios Petrakis.

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The authors declare that they have no competing interests.

Ethical approval

All clinical samples and data were collected during routine patient care.

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Both patients provided signed informed consent for publication.

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Liapis, K., Bouzani, M., Petrakis, V. et al. A variant of KSHV-associated inflammatory cytokine syndrome in elderly men of Mediterranean descent. Infection (2023). https://doi.org/10.1007/s15010-023-02155-z

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  • DOI: https://doi.org/10.1007/s15010-023-02155-z

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