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Short report: impact of selective reporting of antibiotic susceptibility testing on antibiotic use in patients with bloodstream infection with Enterococcus faecalis

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Abstract

Introduction

Bloodstream infections with Enterococcus faecalis are associated with relevant morbidity and mortality. Targeted antimicrobial therapy is essential. The choice of an adequate treatment may be challenging when susceptibility testing offers different options. Selective reporting of antibiotic susceptibility test results might lead to a more tailored antibiotic therapy and could therefore be an important antimicrobial stewardship program intervention. The aim of this study was to analyse whether the introduction of selective reporting of antibiotic test results leads to a more targeted antibiotic therapy in patients with bloodstream infection with Enterococcus faecalis.

Methods

This study was performed as a retrospective cohort study at the University Hospital Regensburg, Germany. All patients with blood cultures positive for Enterococcus faecalis between March 2003 and March 2022 were analysed. In February 2014 selective reporting of antibiotic susceptibility test results omitting sensitivity results for agents not recommended was introduced.

Results

263 patients with blood cultures positive for Enterococcus faecalis were included. After introduction of selective reporting of antibiotic tests (AI) significantly more patients received ampicillin than before introduction of selective reporting (BI) (9.6% BI vs. 34.6% AI, p < 0.001).

Conclusion

Selective reporting of antibiotic susceptibility test results led to a significantly higher use of ampicillin.

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Data availability

The dataset analysed during the current study is available from the corresponding author upon reasonable request.

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Funding

The authors did not receive support from any organization for the submitted work.

Author information

Authors and Affiliations

  1. Center for Pneumology, Donaustauf Hospital, Ludwigstraße 68, 93093, Donaustauf, Germany

    Florian Geismann, Stefan Handschuh, Maximilian Malfertheiner & Arno Mohr

  2. Department of Internal Medicine 2, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany

    Clemens Wiest

  3. Department of Infection Prevention and Infectious Diseases, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany

    Bernd Salzberger, Stilla Bauernfeind, Florian Hitzenbichler, Aila Caplunik-Pratsch & Wulf Schneider-Brachert

  4. Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany

    Tamara Ruegamer

  5. Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Kerpener Str. 62, 50937, Cologne, Germany

    Michaela Simon

Authors
  1. Florian Geismann
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Contributions

FG, SH and AM wrote the main manuscript text. SH and TR collected the data. FG and AM analysed the data. MM, BS, SB, MS, ACP, WSB, CW and TR reviewed the manuscript.

Corresponding author

Correspondence to Florian Geismann.

Ethics declarations

Conflict of interest

AM received travel grants from Gilead, BS received a consulting honorarium from Roche AG. All other authors declare they have no financial interests.

Ethical approval

The study was approved by the institutional ethics committee (No. 21-2406-104; due. to the noninterventional and retrospective nature of our study the need for informed consent was waived).

Consent to participate and consent to publish

According to the ethics committee, this retrospective analysis and publication can be done without written consent of the patients.

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Geismann, F., Handschuh, S., Malfertheiner, M. et al. Short report: impact of selective reporting of antibiotic susceptibility testing on antibiotic use in patients with bloodstream infection with Enterococcus faecalis. Infection 51, 1557–1562 (2023). https://doi.org/10.1007/s15010-023-02045-4

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