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Effectiveness of a Blended Internet-Based Mindfulness Intervention in Inflammatory Bowel Disease Patients: a Mixed-Methods Non-randomized Controlled Trial

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Abstract

Objectives

Patients with inflammatory bowel disease (IBD) usually experience psychosocial impairment and psychiatric comorbidity related to the chronic course, relapsing activity (unpredictable risk of flare), and consequent physical symptoms. One of the psychological approaches which has gained more consideration as a coadjuvant therapy is mindfulness-based intervention (MBI). The purpose of this study was to examine the efficacy of a blended Internet-based MBI compared to standard medical therapy (SMT), in a sample of patients with IBD.

Methods

A mixed-methods non-randomized controlled trial was conducted with 57 patients with IBD (35 in MBI condition and 22 in SMT condition). The MBI involved an 8-week program which comprised four face-to-face support sessions and four Internet-based therapy modules. Health-related quality of life (HRQoL), anxiety, depression, stress, mindfulness, and optimism were compared within and between groups. Qualitative methods were used to analyze the response of the patients to the treatment.

Results

Results revealed that the MBI condition significantly increased HRQoL and optimism compared to the SMT condition. However, there were no significant between-group differences in anxiety, depression, perceived stress, pessimism, or mindfulness facets. In addition, the interviewed MBI participants (n = 19) assured that they had learned strategies to regulate their emotions (anxiety, depression, stress) and to manage both pain and fatigue.

Conclusions

This study shows the effectiveness of a blended Internet-based MBI in increasing HRQoL and optimism in patients with IBD. It also highlights the use of MBIs to treat psychological impairment in IBD.

Trial Registration.

NCT 02,963,246, 15/11/2016.

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Acknowledgements

We thank CIBEROBN, an initiative of the ISCIII (ISC III CB06 03/0052).

Author information

Authors and Affiliations

  1. Department of Personality, Evaluation, and Psychological Treatments, University of Valencia, Valencia, Spain

    Ausiàs Cebolla, Jaime Navarrete & Rosa M. Baños

  2. CiberObn Pathophysiology of Obesity and Nutrition (CB06/03), Instituto Salud Carlos III, Madrid, Spain

    Ausiàs Cebolla, Rosa M. Baños & Juan Francisco Lisón

  3. Department of Nursing, Universidad Cardenal Herrera CEU, CEU Universities, Castellon, Spain

    Rafael González-Moret

  4. Internal Medicine Service, Digestive Medicine Section, Hospital Universitario de Sagunto, Valencia, Spain

    Xavier Cortés

  5. Department of Biomedical Sciences, Facultad de Ciencias de La Salud, Universidad Cardenal Herrera CEU, CEU Universities, Carrer Santiago Ramón y Cajal 20, 46115, Valencia, Spain

    José Miguel Soria & Juan Francisco Lisón

  6. Odisesas Institute, Universidad CEU Cardenal Herrera, CEU Universities, Carrer Santiago Ramón Y Cajal, 20, 46115, Valencia, Spain

    José Miguel Soria

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  3. Rafael González-Moret
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  4. Xavier Cortés
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  5. José Miguel Soria
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  6. Rosa M. Baños
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  7. Juan Francisco Lisón
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Contributions

X.C. and R.G-M. performed the recruitment. J.N. conducted the formal analyses and wrote the results section. A.C., J.N., and R.M.B. wrote the original draft. J.M.S., J.F.L., R.G-M., and X.C. collaborated in the writing and editing of the final manuscript. All authors approved the final version of the manuscript for submission.

Corresponding author

Correspondence to Juan Francisco Lisón.

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Ethics Approval

This non-randomized single-center controlled trial (NCT02963246, 15/11/2016) was approved by the Ethics Committee at the Hospital Universitario de Sagunto (Spain) and complied with the ethical guidelines set out in the Declaration of Helsinki.

Competing Interests

The authors declare no competing interests.

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Cebolla, A., Navarrete, J., González-Moret, R. et al. Effectiveness of a Blended Internet-Based Mindfulness Intervention in Inflammatory Bowel Disease Patients: a Mixed-Methods Non-randomized Controlled Trial. Mindfulness 12, 2767–2780 (2021). https://doi.org/10.1007/s12671-021-01741-2

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