Abstract
Damaged peripheral nerves undergo peripheral neurodegenerative processes that are essential for the nerve regeneration. Peripheral neurodegenerative diseases, including diabetic peripheral neuropathy, are induced by irreversible nerve damage caused by abnormal peripheral nerve degeneration. However, until now, there have been no effective therapeutic treatments for these diseases. Ginsenosides are the most pharmacologically active compounds in Panax ginseng, and are being actively studied. Ginsenosides have a variety of effects, including neuroprotective, antioxidative, anti-cytotoxic, and anti-inflammatory effects. Here, we investigated the efficacy of 18 ginsenosides. We then tested the ability of the most effective ginsenoside, (S)-ginsenosides F1 (sF1), to inhibit peripheral neurodegenerative processes using mouse sciatic ex vivo culture, and several morphological and biochemical indicators. Our results suggest that sF1 could effectively protect Schwann cells against peripheral nerve degeneration.
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Acknowledgements
We thank Ms. Nahyeon Kim (Department of Anatomy and Neurobiology, Kyung Hee University, Seoul, Korea) for her valuable discussion. This work was supported by Basic Science Research Program through National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (Grant No. 2018R1D1A1B07040282) and a grant from Kyung Hee University in 2019 (KHU-20191219).
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YLC, SL, KHP, CP, YH, NYJ and JJ designed this study and interpreted experimental results. YLC, SL, CP, YH, NYJ and JJ defined intellectual contents. YLC, SL, NYJ and JJ performed experiments. YLC, NYJ and JJ wrote the manuscript. YH and JJ obtained funds from Kyung Hee University and government, respectively. All authors read and approved the final manuscript.
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Chun, Y.L., Lee, S., Park, KH. et al. Protective and therapeutic effect of (S)-ginsenoside F1 on peripheral nerve degeneration targeting Schwann cells: a pharmaco-neuroanatomical approach. Anat Sci Int 97, 79–89 (2022). https://doi.org/10.1007/s12565-021-00630-x
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DOI: https://doi.org/10.1007/s12565-021-00630-x