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Evaluation of a Rabbit Model of Vascular Stent Healing: Application of Optical Coherence Tomography

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A Correction to this article was published on 05 July 2023

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Abstract

Percutaneous coronary intervention (PCI) is a management strategy for symptomatic obstructive coronary artery disease (CAD). Despite advancements, in-stent restenosis (ISR) still imparts a 1–2% annual rate of repeat revascularization—a focus of ongoing translational research. Optical coherence tomography (OCT) provides high resolution virtual histology of stents. Our study evaluates the use of OCT for virtual histological assessment of stent healing in a rabbit aorta model, enabling complete assessment of intraluminal healing throughout the stent. ISR varies based on intra-stent location, stent length, and stent type in a rabbit model—important considerations for translational experimental design. Atherosclerosis leads to more prominent ISR proliferation independent of stent-related factors. The rabbit stent model mirrors clinical observations, while OCT-based virtual histology demonstrates utility for pre-clinical stent assessment. Pre-clinical models should incorporate clinical and stent factors as feasible to maximize translation to clinical practice.

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Funding

This work was supported by the UOHIAMO AFP Innovations Funding Competition for Innovative Clinical Projects and CFI (Canadian Foundation for Innovation). The Vered-Beanlands Endowed Fellowship (TS). The Canadian Institutes of Health Research (Vanier Research Graduate Scholarship (RGJ) and Banting Postdoctoral Fellowship (FDR)), the Royal College of Physicians and Surgeons of Canada (Detweiler Travelling Fellowship (FDR)) .

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  1. Trevor Simard and Richard Jung are equally contributing authors.

Authors and Affiliations

  1. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA

    Trevor Simard, Dhruv Sarma, David R. Holmes & Mohamad Alkhouli

  2. Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Room H4238, Ottawa, ON, Canada

    Trevor Simard, Richard Jung, Pietro Di Santo, Kiran Sarathy, Kamran Majeed, Pouya Motazedian, Spencer Short, Shan Dhaliwal, Alisha Labinaz, F. Daniel Ramirez, Michael Froeschl, Marino Labinaz & Benjamin Hibbert

  3. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada

    Trevor Simard, Richard Jung & Benjamin Hibbert

  4. Department of Cardiology, Prince of Wales Hospital, Sydney, Australia

    Kiran Sarathy

  5. Department of Cardiology, Royal Perth Hospital, Perth, WA, Australia

    Kamran Majeed

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Clinical Relevance

• Percutaneous coronary intervention remains limited by a 1–2% annual rate of repeat revascularization—a focus of ongoing clinical and pre-clinical research.

• We demonstrate a pre-clinical rabbit model enabling pragmatic evaluation of stent healing with virtual histology via optical coherence tomography.

The original version of this article was revised: The graphical abstract originally published for this article contained an inaccuracy and has been replaced.

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Simard, T., Jung, R., Di Santo, P. et al. Evaluation of a Rabbit Model of Vascular Stent Healing: Application of Optical Coherence Tomography. J. of Cardiovasc. Trans. Res. 16, 1194–1204 (2023). https://doi.org/10.1007/s12265-023-10399-1

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