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Renal crystal-storing histiocytosis successfully treated with bortezomib-based regimen

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Summary

Crystal-storing histiocytosis (CSH) represents a rare disease seen in patients with monoclonal gammopathy of unknown significance, multiple myeloma, lymphoplasmocytic lymphoma, and other hematological disorders. In the kidneys, it commonly involves the interstitium but can also involve the glomeruli or the vasculature. Herein we present a case of CSH involving the renal interstitium in a patient who presented with rapidly progressing renal failure. He was treated with cyclophosphamide, dexamethasone and bortezomib-based chemotherapy and afterwards his renal function improved back to baseline. CSH is a rare monoclonal gammopathy affecting the kidneys. The underlying clonal cell type of the aberrant monoclonal protein can be identified, which might help in optimizing the treatment strategy and further patient management.

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Fig. 1
Fig. 2

Abbreviations

AKI:

Acute kidney injury

CSH:

Crystal-storing histiocytosis

IHC:

Immunohistochemistry

MGRS:

Monoclonal gammopathy of renal significance

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Acknowledgements

Manipal hospitals Bangalore.

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Authors and Affiliations

  1. Department of Nephrology, Manipal Hospitals, Bangalore, India

    Poornima Tadkal &  Siddini Vishwanath

  2. Department of Pathology, Manipal Hospitals, Bangalore, India

    Vankalakunti Mahesha

  3. Manipal Hospitals, Bangalore, India

    Kishore Babu

  4. Department of Hematology, Manipal Hospitals, Bangalore, India

    Mallikarjun Kalashetty

Authors
  1. Poornima Tadkal
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  2. Siddini Vishwanath
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  3. Vankalakunti Mahesha
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  4. Kishore Babu
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  5. Mallikarjun Kalashetty
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Contributions

PT grafted the manuscript. VS treated the patient and contibuted to writing the manuscript. MV contributed to analyzing the histopathology. MK assisted in treatment and follow-up. All authors read and approved the manuscript.

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Correspondence to Poornima Tadkal.

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P. Tadkal, S. Vishwanath, V. Mahesha, K. Babu and M. Kalashetty declare that they have no competing interests.

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Tadkal, P., Vishwanath, S., Mahesha, V. et al. Renal crystal-storing histiocytosis successfully treated with bortezomib-based regimen. memo 17, 57–62 (2024). https://doi.org/10.1007/s12254-023-00922-0

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  • DOI: https://doi.org/10.1007/s12254-023-00922-0

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