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Verification of optimal conditions for the scattering correction of 123I-FP-CIT SPECT on a single-photon emission tomography system with a two-detector whole-body cadmium–zinc–telluride semiconductor detector

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Abstract

To identify the optimal scattering correction for 123I-FP-CIT SPECT (DAT-SPECT) using a two-detector whole-body cadmium–zinc–telluride semiconductor detector (C-SPECT) system with a medium-energy high-resolution sensitivity (MEHRS) collimator. The C-SPECT system with the MEHRS collimator assessed image quality and quantification using a striated phantom. Different reconstruction methods and scattering correction settings were compared, including filtered back projection (FBP) and ordered subset expectation maximization (OSEM). Higher %contrast and %CV values were observed > 10% subwindow (SW) for all conditions, with no significant differences between images without scattering correction and those < 7% SW. The FBP images show a greater increase in %CV > 10% SW than the OSEM images. The specific binding ratio in the radioactivity ratio of 8:1 was higher than the true value under all conditions. The C-SPECT system with an MEHRS collimator provided accurate scattering suppression and enabled high-quality imaging for DAT-SPECT. Careful setting of the scattering correction is essential for total count accuracy.

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Data availability

Owing to the sensitive nature of the questions asked in this study, survey respondents were assured that the raw data would remain confidential and would not be shared. The data that has been used is confidential.

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Acknowledgements

We thank the staff at the Department of Radiology, Saiseikai Yokohamashi Tobu Hospital, for providing technical support.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Office of Radiation Technology, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Daisuke Izawa

  2. Department of Radiological, Technology, Faculty of Medical Technology, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan

    Toshimune Ito

  3. Department of Central Radiology, Teikyo University Mizonokuchi Hospital, 5-1-1 Futago, Takatsu-ku, Kawasaki, Kanagawa, 213-8507, Japan

    Hiroki Sanada & Hitoshi Hiraki

  4. Department of Radiology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan

    Takuma Oku

  5. Department of Central Radiology, Juntendo University Hospital, 3-1-3 Hongou, Bunkyo-ku, Tokyo, 113-8431, Japan

    Ayaka Nakamoto

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  1. Daisuke Izawa
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by TI, HS, TO, and AN. The first draft of the manuscript was written by DI and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Toshimune Ito.

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Izawa, D., Ito, T., Sanada, H. et al. Verification of optimal conditions for the scattering correction of 123I-FP-CIT SPECT on a single-photon emission tomography system with a two-detector whole-body cadmium–zinc–telluride semiconductor detector. Radiol Phys Technol 16, 569–577 (2023). https://doi.org/10.1007/s12194-023-00746-x

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  • DOI: https://doi.org/10.1007/s12194-023-00746-x

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