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Patch-based artifact reduction for three-dimensional volume projection data of sparse-view micro-computed tomography

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Abstract

Micro-computed tomography (micro-CT) enables the non-destructive acquisition of three-dimensional (3D) morphological structures at the micrometer scale. Although it is expected to be used in pathology and histology to analyze the 3D microstructure of tissues, micro-CT imaging of tissue specimens requires a long scan time. A high-speed imaging method, sparse-view CT, can reduce the total scan time and radiation dose; however, it causes severe streak artifacts on tomographic images reconstructed with analytical algorithms due to insufficient sampling. In this paper, we propose an artifact reduction method for 3D volume projection data from sparse-view micro-CT. Specifically, we developed a patch-based lightweight fully convolutional network to estimate full-view 3D volume projection data from sparse-view 3D volume projection data. We evaluated the effectiveness of the proposed method using physically acquired datasets. The qualitative and quantitative results showed that the proposed method achieved high estimation accuracy and suppressed streak artifacts in the reconstructed images. In addition, we confirmed that the proposed method requires both short training and prediction times. Our study demonstrates that the proposed method has great potential for artifact reduction for 3D volume projection data under sparse-view conditions.

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Acknowledgements

This research was partly supported by the Japan Society for the Promotion of Science (JSPS), KAKENHI Grant-in-Aid for Scientific Research (A), grant number 19H01172. We wish to thank Machiko Horiuchi from Summit Pharma International Corporation (Tokyo, Japan) for technical assistance with the micro-CT scan experiments.

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Authors and Affiliations

  1. Graduate School of Science and Engineering, Chiba University, Chiba, 263-8522, Japan

    Takayuki Okamoto & Toshio Kumakiri

  2. Center for Frontier Medical Engineering, Chiba University, Chiba, 263-8522, Japan

    Hideaki Haneishi

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  1. Takayuki Okamoto
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Correspondence to Takayuki Okamoto.

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Hideaki Haneishi received an unnumbered research grant from Rigaku Corporation (Tokyo, Japan) for research separate from the submitted work.

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Okamoto, T., Kumakiri, T. & Haneishi, H. Patch-based artifact reduction for three-dimensional volume projection data of sparse-view micro-computed tomography. Radiol Phys Technol 15, 206–223 (2022). https://doi.org/10.1007/s12194-022-00661-7

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