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Modification of Gut Microbiota in Inflammatory Arthritis: Highlights and Future Challenges

  • Rheumatoid Arthritis (L Moreland, Section Editor)
  • Published:
Current Rheumatology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This Review evaluates the available information on the modification of the microbiota by diet, prebiotics, probiotics, or drugs and its association with the severity of arthritis in animals and humans and highlights how this modulation could have therapeutic applications in RA.

Recent Findings

The gut microbiota and microbiota-derived metabolites play a role in developing rheumatoid arthritis (RA) in animals and humans, making the intestinal microbiota an exciting novel approach to suppress autoimmunity.

Summary

Studies in animal models of RA show that it is possible to modify the intestinal microbiota with drugs, natural products, diet, probiotics, and prebiotics. Furthermore, these changes showed beneficial effects on symptom relief in animal models of RA and that these effects were associated with modulation of the immune response. Therapies that modify the gut microbiota would significantly impact the preclinical stage of arthritis, based on the fact that dysbiosis occurs before clinical arthritis. The effects of interventions to modulate the microbiota could not reverse arthritis. Furthermore, the therapies modulating therapies in controlling symptoms were limited once arthritis developed. The results obtained in the study of acarbose, probiotics, and prebiotics suggest that these interventions may decrease the disease's incidence rather than treat or cure it.

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References

  1. Catrina AI, Deane KD, Scher JU. Gene, environment, microbiome and mucosal immune tolerance in rheumatoid arthritis. Rheumatology (Oxford). 2016;55:391–402.

    CAS  Google Scholar 

  2. Ribeiro CFA, Silveira G, Candido ES, Cardoso MH, Espinola Carvalho CM, Franco OL. Effects of Antibiotic Treatment on Gut Microbiota and How to Overcome Its Negative Impacts on Human Health. ACS Infect Dis. 2020;6:2544–59.

    Article  CAS  PubMed  Google Scholar 

  3. Liu X, Zeng B, Zhang J, Li W, Mou F, Wang H, et al. Role of the gut microbiome in modulating arthritis progression in mice. Sci Rep. 2016;6:30594.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Amat S, Lantz H, Munyaka PM, Willing BP Prevotella in pigs: the positive and negative associations with production and health. Microorganisms (2020) 8:

  5. Rogier R, Ederveen THA, Wopereis H, Hartog A, Boekhorst J, van Hijum SAFT, et al. Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice. PLoS One. 2019;14:e0219366.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Horta-Baas G, Romero-Figueroa MDS, Montiel-Jarquin AJ, Pizano-Zarate ML, Garcia-Mena J, Ramirez-Duran N. Intestinal dysbiosis and rheumatoid arthritis: a link between gut microbiota and the pathogenesis of rheumatoid arthritis. J Immunol Res. 2017;2017:4835189.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Maeda Y, Takeda K. Role of gut microbiota in rheumatoid arthritis. J Clin Med. 2017;6.

  8. Zhang X, Chen BD, Zhao LD, Li H. The gut microbiota: emerging evidence in autoimmune diseases. Trends Mol Med. 2020;26:862–73.

    Article  CAS  PubMed  Google Scholar 

  9. Wells PM, Adebayo AS, Bowyer RCE, Freidin MB, Finckh A, Strowig T, et al. Associations between gut microbiota and genetic risk for rheumatoid arthritis in the absence of disease: a cross-sectional study. Lancet Rheumatol. 2020;2:e418.427.

    Article  Google Scholar 

  10. Deane KD, Striebich CC, Holers VM. Editorial: prevention of rheumatoid arthritis: now is the time, but how to proceed? Arthritis Rheum. 2017;69:873–7.

    Article  Google Scholar 

  11. Larsen JM. The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017;151:363–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Mizuno M, Noto D, Kaga N, Chiba A, Miyake S. The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models. PLoS One. 2017;12:e0173032.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Xu H, Zhao H, Fan D, Liu M, Cao J, Xia Y, et al. Interactions between gut microbiota and immunomodulatory cells in rheumatoid arthritis. Mediat Inflamm. 2020;2020:1430605.

    Article  Google Scholar 

  14. Amdekar S, Singh V, Kumar A, Sharma P, Singh R. Lactobacillus casei and Lactobacillus acidophilus regulate inflammatory pathway and improve antioxidant status in collagen-induced arthritic rats. J Interf Cytokine Res. 2013;33:1–8.

    Article  CAS  Google Scholar 

  15. Esvaran M, Conway PL Lactobacillus fermentum PC1 has the capacity to attenuate joint inflammation in collagen-induced arthritis in DBA/1 mice. Nutrients (2019) 11:

  16. Costea PI, Hildebrand F, Arumugam M, Bäckhed F, Blaser MJ, Bushman FD, et al. Enterotypes in the landscape of gut microbial community composition. Nat Microbiol. 2018;3:8–16.

    Article  CAS  PubMed  Google Scholar 

  17. Rogier R, Evans-Marin H, Manasson J, van der Kraan PM, Walgreen B, Helsen MM, et al. Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis. Sci Rep. 2017;7:15613.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Wu X, Tian J, Wang S. Insight into non-pathogenic Th17 cells in autoimmune diseases. Front Immunol. 2018;9:1112.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Rosser EC, Oleinika K, Tonon S, Doyle R, Bosma A, Carter NA, et al. Regulatory B cells are induced by gut microbiota-driven interleukin-1beta and interleukin-6 production. Nat Med. 2014;20:1334–9.

    Article  CAS  PubMed  Google Scholar 

  20. Block KE, Zheng Z, Dent AL, Kee BL, Huang H. Gut Microbiota Regulates K/BxN Autoimmune Arthritis through Follicular Helper T but Not Th17 Cells. J Immunol. 2016;196:1550–7.

    Article  CAS  PubMed  Google Scholar 

  21. Jubair WK, Hendrickson JD, Severs EL, Schulz HM, Adhikari S, Ir D, et al. Modulation of inflammatory arthritis in mice by gut microbiota through mucosal inflammation and autoantibody generation. Arthritis Rheum. 2018;70:1220–33.

    Article  CAS  Google Scholar 

  22. Xu H, Cao J, Li X, Lu X, Xia Y, Fan D, et al. Regional Differences in the gut microbiota and gut-associated immunologic factors in the ileum and cecum of rats with collagen-induced arthritis. Front Pharmacol. 2020;11:587534.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Zeng J, Peng L, Zheng W, Huang F, Zhang N, Wu D, et al. Fecal microbiota transplantation for rheumatoid arthritis: A case report. Clin Case Rep. 2021;9:906–9.

    Article  PubMed  Google Scholar 

  24. Zaragoza-Garcia O, Castro-Alarcon N, Perez-Rubio G, Guzman-Guzman IP. DMARDs-Gut Microbiota Feedback: Implications in the Response to Therapy. Biomolecules. 2020;10.

  25. Zhang L, Song P, Zhang X, et al. Alpha-glucosidase inhibitors alter gut microbiota and ameliorate collagen-induced arthritis. Front Pharmacol. 2019;10:1684.

    Article  CAS  PubMed  Google Scholar 

  26. Jethwa H, Abraham S. The evidence for microbiome manipulation in inflammatory arthritis. Rheumatology (Oxford). 2017;56:1452–60.

    CAS  Google Scholar 

  27. Zhang X, Zhang D, Jia H, Feng Q, Wang D, Liang D, et al. The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment. Nat Med. 2015;21:895–905.

    Article  CAS  PubMed  Google Scholar 

  28. Letertre MPM, Munjoma N, Wolfer K, Pechlivanis A, McDonald JAK, Hardwick RN, et al. A two-way interaction between methotrexate and the gut microbiota of male Sprague-Dawley rats. J Proteome Res. 2020;19:3326–39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Zhou B, Xia X, Wang P, Chen S, Yu C, Huang R, et al. Induction and amelioration of methotrexate-induced gastrointestinal toxicity are related to immune response and gut microbiota. EBioMedicine. 2018;33:122–33.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Artacho A, Isaac S, Nayak R, et al. The pre-treatment gut microbiome is associated with lack of response to methotrexate in new onset rheumatoid arthritis. Arthritis Rheumatol (2020)

  31. Yue M, Tao Y, Fang Y, Lian X, Zhang Q, Xia Y, et al. The gut microbiota modulator berberine ameliorates collagen-induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply. FASEB J. 2019;33:12311–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Wang B, He Y, Tang J, Ou Q, Lin J. Alteration of the gut microbiota in tumor necrosis factor-alpha antagonist-treated collagen-induced arthritis mice. Int J Rheum Dis. 2020;23:472–9.

    Article  CAS  PubMed  Google Scholar 

  33. Picchianti-Diamanti A, Panebianco C, Salemi S, et al. Analysis of gut microbiota in rheumatoid arthritis patients: disease-related dysbiosis and modifications induced by etanercept. Int J Mol Sci. 2018:19.

  34. Guo LX, Wang HY, Liu XD, et al. Saponins from Clematis mandshurica Rupr. regulates gut microbiota and its metabolites during alleviation of collagen-induced arthritis in rats. Pharmacol Res. 2019;149:104459.

    Article  CAS  PubMed  Google Scholar 

  35. Lee S, Koh J, Chang Y, Kim HY, Chung DH. Invariant NKT cells functionally link microbiota-induced butyrate production and joint inflammation. J Immunol. 2019;203:3199–208.

    Article  CAS  PubMed  Google Scholar 

  36. Huang Y, Li M, Zhou L, Xu D, Qian F, Zhang J, et al. Effects of Qingluo Tongbi decoction on gut flora of rats with adjuvant-induced arthritis and the underlying mechanism. Evid Based Complement Alternat Med. 2019;2019:6308021.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Peng J, Lu X, Xie K, Xu Y, He R, Guo L, et al. Dynamic alterations in the gut microbiota of collagen-induced arthritis rats following the prolonged administration of total glucosides of paeony. Front Cell Infect Microbiol. 2019;9:204.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Albenberg LG, Wu GD. Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology. 2014;146:1564–72.

    Article  CAS  PubMed  Google Scholar 

  39. De Filippis F, Pasolli E, Tett A, et al. Distinct genetic and functional traits of human intestinal Prevotella copri strains are associated with different habitual diets. Cell Host Microbe. 2019;25(444-453):e443.

    Google Scholar 

  40. Diamanti AP, Manuela Rosado M, Lagana B, D’Amelio R. Microbiota and chronic inflammatory arthritis: an interwoven link. J Transl Med. 2016;14:233.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  41. Singh RK, Chang HW, Yan D, Lee KM, Ucmak D, Wong K, et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15:73.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  42. Mansson I, Norberg R, Olhagen B, Bjorklund NE. Arthritis in pigs induced by dietary factors. Microbiologic, clinical and histologic studies. Clin Exp Immunol. 1971;9:677–93.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Inda ME, Broset E, Lu TK, de la Fuente-Nunez C. Emerging frontiers in microbiome engineering. Trends Immunol. 2019;40:952–73.

    Article  CAS  PubMed  Google Scholar 

  44. Galvez EJC, Iljazovic A, Amend L, et al. Distinct polysaccharide utilization determines interspecies competition between intestinal Prevotella spp. Cell Host Microbe. 2020;28(838-852):e836.

    Google Scholar 

  45. Rodrigues GSP, Cayres LCF, Goncalves FP, Takaoka NNC, Lengert AH, Tansini A, Brisotti JL, Sasdelli CBG, Oliveira GLV Detection of increased relative expression units of Bacteroides and Prevotella, and decreased Clostridium leptum in stool samples from Brazilian rheumatoid arthritis patients: a pilot study. Microorganisms (2019) 7:

  46. Takahashi D, Hoshina N, Kabumoto Y, Maeda Y, Suzuki A, Tanabe H, et al. Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine. 2020;58:102913.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Kang Y, Cai Y, Zhang X, Kong X, Su J. Altered gut microbiota in RA: implications for treatment. Z Rheumatol. 2017;76:451–7.

    Article  CAS  PubMed  Google Scholar 

  48. Fernandez-Llanio Comella N, Fernandez Matilla M, Castellano Cuesta JA. Have complementary therapies demonstrated effectiveness in rheumatoid arthritis? Reumatol Clin. 2016;12:151–7.

    Article  PubMed  Google Scholar 

  49. Peltonen R, Kjeldsen-Kragh J, Haugen M, Tuominen J, Toivanen P, Forre O, et al. Changes of faecal flora in rheumatoid arthritis during fasting and one-year vegetarian diet. Br J Rheumatol. 1994;33:638–43.

    Article  CAS  PubMed  Google Scholar 

  50. Kovatcheva-Datchary P, Nilsson A, Akrami R, Lee YS, De Vadder F, Arora T, et al. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab. 2015;22:971–82.

    Article  CAS  PubMed  Google Scholar 

  51. Flak MB, Colas RA, Munoz-Atienza E, Curtis MA, Dalli J, Pitzalis C. Inflammatory arthritis disrupts gut resolution mechanisms, promoting barrier breakdown by Porphyromonas gingivalis. JCI Insight. 2019;4.

  52. Miranda PM, De Palma G, Serkis V, Lu J, Louis-Auguste MP, McCarville JL, et al. High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production. Microbiome. 2018;6:57.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature. 2017;551:585–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Caslin B, Maguire C, Karmakar A, Mohler K, Wylie D, Melamed E. Alcohol shifts gut microbial networks and ameliorates a murine model of neuroinflammation in a sex-specific pattern. Proc Natl Acad Sci U S A. 2019;116:25808–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Chen ML, Yi L, Zhang Y, Zhou X, Ran L, Yang J, et al. Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota. mBio. 2016;7:e02210–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Hills RD, Jr., Pontefract BA, Mishcon HR, Black CA, Sutton SC, Theberge CR Gut microbiome: profound implications for diet and disease. Nutrients (2019) 11:

  57. Cani PD. Human gut microbiome: hopes, threats and promises. Gut. 2018;67:1716–25.

    Article  CAS  PubMed  Google Scholar 

  58. Jin Song S, Woodhams DC, Martino C, Allaband C, Mu A, Javorschi-Miller-Montgomery S, et al. Engineering the microbiome for animal health and conservation. Exp Biol Med (Maywood). 2019;244:494–504.

    Article  CAS  Google Scholar 

  59. Pan H, Li R, Li T, Wang J, Liu L. Whether probiotic supplementation benefits rheumatoid arthritis patients: a systematic review and meta-analysis. Engineering. 2017;3:115–21.

    Article  CAS  Google Scholar 

  60. Fan Z, Yang B, Ross RP, Stanton C, Zhao J, Zhang H, et al. The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats. Food Funct. 2020;11:3681–94.

    Article  CAS  PubMed  Google Scholar 

  61. Fan Z, Yang B, Ross RP, Stanton C, Shi G, Zhao J, et al. Protective effects of Bifidobacterium adolescentis on collagen-induced arthritis in rats depend on timing of administration. Food Funct. 2020;11:4499–511.

    Article  CAS  PubMed  Google Scholar 

  62. Marietta EV, Murray JA, Luckey DH, Jeraldo PR, Lamba A, Patel R, et al. Suppression of inflammatory arthritis by human gut-derived Prevotella histicola in humanized mice. Arthritis Rheum. 2016;68:2878–88.

    Article  CAS  Google Scholar 

  63. Liu X, Zhang J, Zou Q, Zhong B, Wang H, Mou F, et al. Lactobacillus salivarius Isolated from patients with rheumatoid arthritis suppresses collagen-induced arthritis and increases Treg frequency in mice. J Interf Cytokine Res. 2016;36:706–12.

    Article  CAS  Google Scholar 

  64. Maeda Y, Takeda K. Host-microbiota interactions in rheumatoid arthritis. Exp Mol Med. 2019;51:1–6.

    Article  CAS  PubMed  Google Scholar 

  65. Pan H, Guo R, Ju Y, Wang Q, Zhu J, Xie Y, et al. A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis. Microbiome. 2019;7:107.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Kim J-E, Chae CS, Kim G-C, Hwang W, J-s H, Hwang S-M, et al. Lactobacillus helveticus suppresses experimental rheumatoid arthritis by reducing inflammatory T cell responses. J Funct Foods. 2015;13:350–62.

    Article  CAS  Google Scholar 

  67. Hosoya T, Sakai F, Yamashita M, Shiozaki T, Endo T, Ukibe K, et al. Lactobacillus helveticus SBT2171 inhibits lymphocyte proliferation by regulation of the JNK signaling pathway. PLoS One. 2014;9:e108360.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  68. Yamashita M, Matsumoto K, Endo T, Ukibe K, Hosoya T, Matsubara Y, et al. Preventive Effect of Lactobacillus helveticus SBT2171 on Collagen-Induced Arthritis in Mice. Front Microbiol. 2017;8:1159.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Mandel DR, Eichas K, Holmes J. Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial. BMC Complement Altern Med. 2010;10:1.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  70. Alipour B, Homayouni-Rad A, Vaghef-Mehrabany E, Sharif SK, Vaghef-Mehrabany L, Asghari-Jafarabadi M, et al. Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double-blind clinical trial. Int J Rheum Dis. 2014;17:519–27.

    CAS  PubMed  Google Scholar 

  71. Vaghef-Mehrabany E, Alipour B, Homayouni-Rad A, Sharif SK, Asghari-Jafarabadi M, Zavvari S. Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis. Nutrition. 2014;30:430–5.

    Article  CAS  PubMed  Google Scholar 

  72. Vaghef-Mehrabany E, Homayouni-Rad A, Alipour B, Sharif SK, Vaghef-Mehrabany L, Alipour-Ajiry S. Effects of probiotic supplementation on oxidative stress indices in women with rheumatoid arthritis: a randomized double-blind clinical trial. J Am Coll Nutr. 2016;35:291–9.

    Article  PubMed  Google Scholar 

  73. Zamani B, Golkar HR, Farshbaf S, Emadi-Baygi M, Tajabadi-Ebrahimi M, Jafari P, et al. Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Int J Rheum Dis. 2016;19:869–79.

    Article  CAS  PubMed  Google Scholar 

  74. Pineda Mde L, Thompson SF, Summers K, de Leon F, Pope J, Reid G. A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis. Med Sci Monit. 2011;17:CR347–54.

    PubMed  Google Scholar 

  75. Zamani B, Farshbaf S, Golkar HR, Bahmani F, Asemi Z. Synbiotic supplementation and the effects on clinical and metabolic responses in patients with rheumatoid arthritis: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2017;117:1095–102.

    Article  CAS  PubMed  Google Scholar 

  76. Hui W, Yu D, Cao Z, Zhao X. Butyrate inhibit collagen-induced arthritis via Treg/IL-10/Th17 axis. Int Immunopharmacol. 2019;68:226–33.

    Article  CAS  PubMed  Google Scholar 

  77. Rosser EC, Piper CJM, Matei DE, et al. Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells. Cell Metab. 2020;31(837-851):e810.

    Google Scholar 

  78. Haase S, Haghikia A, Wilck N, Muller DN, Linker RA. Impacts of microbiome metabolites on immune regulation and autoimmunity. Immunology. 2018;154:230–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Doonan J, Tarafdar A, Pineda MA, Lumb FE, Crowe J, Khan AM, et al. The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. Nat Commun. 2019;10:1554.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  80. Coakley G, Harris NL. Helminths and microbiota - partners in arthritis prevention? Nat Rev Rheumatol. 2019;15:454–5.

    Article  CAS  PubMed  Google Scholar 

  81. Pineda MA, Rodgers DT, Al-Riyami L, Harnett W, Harnett MM. ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints. Arthritis Rheum. 2014;66:1492–503.

    Article  CAS  Google Scholar 

  82. Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, et al. Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheum. 2016;68:2646–61.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Servicio de Reumatología, Hospital General Regional número 1, Delegación Yucatán, Instituto Mexicano del Seguro Social, Calle 41 No. 439 x 34. Colonia Industrial, 97150, Mérida, Yucatán, Mexico

    Gabriel Horta-Baas

  2. Laboratorio de alta especialidad en Hemato-Oncología, Hospital para el Niño, IMIEM, Toluca, Mexico

    Antonio Sandoval-Cabrera

  3. Facultad de Medicina, Campus Universitario Siglo XXl, Zinacantepec, State of Mexico, Mexico

    Antonio Sandoval-Cabrera & María del Socorro Romero-Figueroa

  4. Centro de Investigación en Ciencias de la Salud, Campus Norte Huixquilucan, Universidad Anáhuac México, Mexico City, Mexico

    María del Socorro Romero-Figueroa

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  1. Gabriel Horta-Baas
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  2. Antonio Sandoval-Cabrera
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  3. María del Socorro Romero-Figueroa
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Correspondence to Gabriel Horta-Baas.

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Horta-Baas, G., Sandoval-Cabrera, A. & Romero-Figueroa, M. Modification of Gut Microbiota in Inflammatory Arthritis: Highlights and Future Challenges. Curr Rheumatol Rep 23, 67 (2021). https://doi.org/10.1007/s11926-021-01031-9

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