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Cognitive Dysfunction in Heart Failure: Pathophysiology and Implications for Patient Management

  • Comorbidities (J. Tromp, Section Editor)
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Abstract

Purpose of Review

There is increasing recognition of the prevalence and impact of cognitive dysfunction (CD) in heart failure (HF) patients. This contemporary review appraises the evidence for epidemiological association, direct pathophysiological links and emerging pharmacological and non-pharmacological interventions. Furthermore, we present evidence for care models that aim to mitigate the morbidity and poor quality of life associated with these dual processes and propose future work to improve outcomes.

Recent Findings

CD disproportionately affects heart failure patients, even accounting for known comorbid risk factors, and this may extend to subclinical left ventricular dysfunction. Neuroimaging studies now provide evidence of anatomical and functional differences which support previously postulated mechanisms of reduced cerebral blood flow, micro-embolism and systemic inflammation. Interventions such as multidisciplinary ambulatory HF care, education and memory training improve HF outcomes perhaps to a greater degree in those with comorbid CD. Additionally, optimisation of standard heart failure care (cardiac rehabilitation, pharmacological and device therapy) may lead to additional cognitive benefits.

Summary

Epidemiological, neuroimaging and intervention studies provide evidence for the causal association between HF and CD, although evidence for Alzheimer’s dementia is less certain. Specific reporting of cognitive outcomes in HF trials and evaluation of targeted interventions is required to further guide care provision.

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Authors and Affiliations

  1. Department of General Medicine, Alfred Hospital, Melbourne, Australia

    Sylvia Ye & Elizabeth L. Potter

  2. Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia

    Quan Huynh & Elizabeth L. Potter

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  1. Sylvia Ye
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  2. Quan Huynh
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Correspondence to Elizabeth L. Potter.

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Ye, S., Huynh, Q. & Potter, E.L. Cognitive Dysfunction in Heart Failure: Pathophysiology and Implications for Patient Management. Curr Heart Fail Rep 19, 303–315 (2022). https://doi.org/10.1007/s11897-022-00564-z

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