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Association between reported medication adherence and health-related quality of life in adult patients with haemophilia

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Abstract

Background Medication adherence is an important issue, not just health-related, for patients with haemophilia. Poor medication adherence to long-term therapies limits the potential of effective treatments to improve patients’ health-related quality of life. Objective The aim of this study was to investigate the association of reported medication adherence and health-related quality of life in patients with haemophilia. Setting Data were collected from patients at University Hospital Centre Zagreb, Croatia and at University Medical Centre Ljubljana, Slovenia. Method Adult male patients with severe or moderate haemophilia receiving prophylactic treatment were eligible for the study. Main outcome measure Implementation phase of medication adherence was assessed with the self-reported VERITAS-Pro instrument and health-related quality of life with SF-36v2. Results A total of 82 participants were included in the study (median age was 44.50, range 18–73 years). The majority of our participants reported being adherent to medication (83%). Participants showed better health in the mental health domains and Mental Component Summary than in the physical health domains and Physical Component Summary. After controlling for demographic, socioeconomic and clinical predictors, better reported medication adherence explained an additional 4–6% of better health variance in Bodily Pain and Social Functioning domains and Mental Component Summary. Conclusion We found that reported medication adherence can contribute to better health-related quality of life in patients with haemophilia. Since life with a chronic condition is demanding, it is an important finding that medication adherence to replacement therapy can improve life conditions for patients with haemophilia.

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Acknowledgements

The authors would like to thank all the participants who took part in the study. The authors would like to thank the Indiana Hemophilia & Thrombosis Center, Inc. for providing VERITAS-Pro and OptumInsight Life Sciences, Inc. for providing SF-36v2 for use in this study. The authors would also like to thank Bianca Dobson for language editing of this publication.

Funding

No special funding was obtained.

Author information

Authors and Affiliations

  1. Andrija Stampar Teaching Institute of Public Health, Zagreb, Croatia

    Martina Bago & Ivana Prga

  2. Faculty of Humanities and Social Sciences, University of Zagreb, Zagreb, Croatia

    Ana Butkovic

  3. University Medical Center Ljubljana, Ljubljana, Slovenia

    Irena Preloznik Zupan & Barbara Faganel Kotnik

  4. Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    Irena Preloznik Zupan & Barbara Faganel Kotnik

  5. Clinical Hospital Dubrava, Zagreb, Croatia

    Vesna Bacic Vrca

  6. Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

    Vesna Bacic Vrca

  7. University Hospital Centre Zagreb, Zagreb, Croatia

    Silva Zupancic Salek

  8. Faculty of Medicine, University of Zagreb, Zagreb, Croatia

    Silva Zupancic Salek

Authors
  1. Martina Bago
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  2. Ana Butkovic
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  3. Irena Preloznik Zupan
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  7. Silva Zupancic Salek
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Correspondence to Martina Bago.

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Bago, M., Butkovic, A., Preloznik Zupan, I. et al. Association between reported medication adherence and health-related quality of life in adult patients with haemophilia. Int J Clin Pharm 43, 1500–1507 (2021). https://doi.org/10.1007/s11096-021-01270-x

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  • DOI: https://doi.org/10.1007/s11096-021-01270-x

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