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Design and Preparation of Iodinated Brucea Javanica Oil as Dual Functional Anti-Tumor Agent for Treating Hepatocellular Carcinoma

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Pharmaceutical Chemistry Journal Aims and scope

Brucea javanica oil (BJO), a traditional herbal medicine extracted from the seeds of Brucea javanica plant, has been used in the treatment of cancer in China. In order to develop high-efficiency embolic agents with additional anti-cancer effects applied in transarterial chemoembolization (TACE), iodinated Brucea javanica oil (IBJO) has been prepared and investigated. IBJO was successfully synthesized by a facile method that gradually injected hydrogen iodide into BJO. In addition, antiproliferative activity of IBJO and BJO were determined by MTT assay on human hepatocellular cancer cell line HepG2 and by flow cytometry analysis. The results demonstrated the activity of BJO without significant effect after iodination. More importantly, the results of embolic simulative model in vitro revealed that IBJO exhibited excellent embolization effect. These phenomena indicate that IBJO can induce embolism in capillaries, which is consistent with the goal of BJO iodination. It is our hope that the results obtained in these studies would support the development of dual functional agent which can be used in TACE treatment of hepatocellular carcinoma.

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References

  1. A. Boschi, L. Uccelli, L. Duatti, et al., Nucl. Med. Commun., 25(7), 691 – 699 (2004).

    Article  CAS  Google Scholar 

  2. J. L. Raoul, Semin. Nucl. Med., 38(2), S13 – S18 (2008).

    Article  Google Scholar 

  3. J. Bruix and M. Sherman, Hepatology, 42(5), 1208 – 1236 (2005).

    Article  Google Scholar 

  4. E. Boucher, E. Garin, A. Guylligomarc’h, et al., Radiother. Oncol., 82(1), 76 – 82 (2007).

    Article  CAS  Google Scholar 

  5. L. D. Hu, J. L. Zhang, Q. F. Hu, et al., J. Drug Delivery Sci. Technol., 36, 46 – 54 (2016).

    Article  CAS  Google Scholar 

  6. J. Liu, X. E. Huang, G. Y. Tian, et al., Asian Pac. J. Cancer Prev., 14(3), 2009 – 2012 (2013).

    Article  Google Scholar 

  7. K. Turpaev and N. Welsh, Biochem. Biophys. Res. Commun., 460(3), 868 – 872 (2015).

    Article  CAS  Google Scholar 

  8. W. Zhuona, L. Ling, L. Ning, et al., Molecules, 22(6), 931 (2017).

    Article  Google Scholar 

  9. J. H. Chen, S. H. Kim, P. W. Fan, et al., Drug Des. Dev. Ther., 10, 2003 – 2013 (2016).

    CAS  Google Scholar 

  10. N. Z. Wu, D. Da, T. L. Rudoll, et al., Cancer Res., 53(16), 3765 – 3770 (1993).

    CAS  PubMed  Google Scholar 

  11. A. Shao, G. Chen, N. Jiang, et al., Arch. Pharm. Res., 36(8), 993 – 1003 (2013).

    Article  CAS  Google Scholar 

  12. A. J. DeFail, H. D. Edington, S. Matthews, et al., J. Biomed. Mater. Res., Part A, 79(4), 954 – 962 (2006).

    Article  Google Scholar 

  13. A. Ablat, J. Mohamad, K. Awang, et al., Sci. World J., 2014, 786130 (2014).

  14. Q. Zhang, Y. H. Yuan, J. C. Cui, et al., J. Pharm. Biomed. Anal., 124, 143 – 148 (2016).

    Article  CAS  Google Scholar 

  15. H. Zhang, J. Y. Yang, F. Zhou, et al., Evid. Based Complement. Alternat. Med., 2011, 1 – 14 (2011).

    Google Scholar 

  16. Y. X. Cui, Z. M. Wu, X. X. Liu, et al., AAPS PharmSciTech, 11(2), 878 – 884 (2010).

    Article  CAS  Google Scholar 

  17. Y.-L. Nie, K.-X. Liu, X.-Y. Mao, et al., J. Evidence-Based. Med., 5(4), 216 – 225 (2012).

    Article  Google Scholar 

  18. Z. Yan, G. F. Guo and B. Zhang, Chin. J. Integr. Med., 23(2), 153 – 160 (2017).

    Article  CAS  Google Scholar 

  19. A. H. Zou, Y. W. Li, Y. Y. Chen, et al., Colloids Surf., B, 153, 310 – 319 (2017).

    Article  CAS  Google Scholar 

  20. F. Deschamps, G. Farouil, W. Gonzalez, et al., Cardiovasc. Intervent. Radiol., 40(6), 907 – 913 (2017).

    Article  CAS  Google Scholar 

  21. J. M. Jeong, Y. J. Kim, Y. S. Lee, et al., Nucl. Med. Biol., 28(2), 197 – 204 (2001).

    Article  CAS  Google Scholar 

  22. N. Lepareur, V. Ardisson, N. Noiret, et al., Appl. Radiat. Isot., 69(2), 426 – 430 (2011).

    Article  CAS  Google Scholar 

  23. N. S. Zefirov, V. V. Zhdankin, Y. V. Dankov, et al., Tetrahedron Lett., 27(34), 3971 – 3974 (1986).

    Article  CAS  Google Scholar 

  24. J. P. Laine, P. L. Opresko, F. E. Indig, et al., Cancer Res., 63(21), 7136 – 7146 (2003).

    CAS  PubMed  Google Scholar 

  25. W. Xu, X. C. Jiang, Z. Y. Xu, et al., Evid. Based Complement. Alternat. Med., 2016, 5928562 (2016).

    PubMed  PubMed Central  Google Scholar 

  26. Z. B. Gao, P. T. Ding, L. Zhang, et al., Int. J. Pharm., 328(1), 57 – 64 (2007).

    Article  CAS  Google Scholar 

  27. N. A. Ivanova, A. M. Shainurova, O. V. Shitikova, et al., Russ. Chem. Bull., 52(11), 2483 – 2489 (2003).

    Article  CAS  Google Scholar 

  28. D. F. Shellhamer, D. C. Gleason, G. G. Vaughan, et al., J. Fluor. Chem., 123(2), 171 – 176 (2003).

    Article  CAS  Google Scholar 

  29. X. H. Cai, Y. Li, E. R. O’Grady, et al., Int. J. Mass Spectrom., 241(2–3), 271 – 282 (2005).

    Article  CAS  Google Scholar 

  30. C. G. Dos Remedios, C. C. Liew, P. D. Allen, et al., J. Muscle Res. Cell Motil., 24(4–6), 251 – 260 (2003).

    Article  CAS  Google Scholar 

  31. K. Kazekawa, H. Iwata, T. Shimozuru, et al., J. Biomed. Mater. Res., 38(2), 79 – 86 (1997).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors greatly appreciate Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (PPZY2015B146) and 2018 Innovative Research Team of Jiangsu Province for support of this research work.

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Jiangnan University, Wuxi, 214122, China

    Zhaoqi Yang, Yiyang Wu, Sen Li, Senyi Gong, Yanfei Cai & Jian Jin

  2. State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China

    Zhaoqi Yang & Hanshi Zhong

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  1. Zhaoqi Yang
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  2. Hanshi Zhong
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  3. Yiyang Wu
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  4. Sen Li
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  5. Senyi Gong
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  6. Yanfei Cai
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  7. Jian Jin
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Correspondence to Zhaoqi Yang.

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Yang, Z., Zhong, H., Wu, Y. et al. Design and Preparation of Iodinated Brucea Javanica Oil as Dual Functional Anti-Tumor Agent for Treating Hepatocellular Carcinoma. Pharm Chem J 56, 838–843 (2022). https://doi.org/10.1007/s11094-022-02717-9

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  • DOI: https://doi.org/10.1007/s11094-022-02717-9

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