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Synthesis and Evaluation of New 5,15-Diarylporphyrin Derivatives for Photodynamic Therapy

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Pharmaceutical Chemistry Journal Aims and scope

Two new 5,15-diarylporphyrin derivatives (L1 and L2) were designed and synthesized and their anti-esophageal cancer effects as photosensitizers were evaluated. Both compounds have strong absorption band at 645 – 655 nm in UV-Vis spectra, obvious singlet oxygen generation ability, and fluorescence emission around 657 – 674 nm under laser excitation. Under photodynamic therapy (PDT) conditions, they could significantly inhibit the growth of Eca-109 tumor cells. In particular, compound L1 exhibited excellent photodynamic antiproliferative effect and is worthy of further development.

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Authors and Affiliations

  1. Department of Pharmaceutical Science and Technology, College of Chemistry and Biology, Donghua University, Shanghai, 201620, China

    Yin Liu, Ya-Xin Ding, Le Mi, Yi-Jia Yan & Zhi-Long Chen

  2. Pudong New Area People’s Hospital, Shanghai, 201200, China

    Yan Qiu & Hui Jin

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  1. Yin Liu
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  2. Ya-Xin Ding
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  3. Le Mi
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  4. Yan Qiu
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  5. Yi-Jia Yan
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  6. Hui Jin
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  7. Zhi-Long Chen
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Correspondence to Zhi-Long Chen.

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Liu, Y., Ding, YX., Mi, L. et al. Synthesis and Evaluation of New 5,15-Diarylporphyrin Derivatives for Photodynamic Therapy. Pharm Chem J 56, 790–797 (2022). https://doi.org/10.1007/s11094-022-02711-1

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  • DOI: https://doi.org/10.1007/s11094-022-02711-1

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