A series of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitriles were synthesized. Their antiproliferative activity was studied. Substituents in the pyridine ring 5- and 6-positions influenced the activity of the molecules. 2-Oxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridine-3,4-dicarbonitrile and 2-oxo-6-tert-butyl-1,2,5,6,7,8-hexahydroquinoline-3,4-dicarbonitrile slightly inhibited the growth of leukemia (with a tendency to a greater degree for K-562 and SR), brain cancer (with a tendency to a greater degree for SNB-75), prostate cancer (with a tendency to a greater degree of PC-3), and breast cancer cell lines (with a tendency to a greater degree for MCF-7).
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ACKNOWLEDGMENTS
The work was performed through a grant from the RF President for State Support of Young Russian Scientists, Contract No. 075-15-2020-229 (MK-269.2020.3).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 3, pp. 25 – 28, March, 2022.
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Fedoseev, S.V., Lipin, K.V. & Ershov, O.V. Synthesis and Antiproliferative Activity of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitriles. Pharm Chem J 56, 325–328 (2022). https://doi.org/10.1007/s11094-022-02638-7
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DOI: https://doi.org/10.1007/s11094-022-02638-7