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Bacillus Calmette-Guérin (BCG)-Induced Protection in Brain Disorders

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Abstract

The Bacille Calmette-Guerin (BCG) vaccine is one of the most widely used vaccines in the world for the prevention of tuberculosis. Its immunological capacity also includes epigenetic reprogramming, activation of T cells and inflammatory responses. Although the main usage of the vaccine is the prevention of tuberculosis, different works have shown that the effect of BCG can go beyond the peripheral immune response and be linked to the central nervous system by modulating the immune system at the level of the brain. This review therefore aims to describe the BCG vaccine, its origin, its relationship with the immune system, and its involvement at the brain level.

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ACKNOWLEDGEMENTS

To the University of Southern Santa Catarina. To the Laboratory of Cerebrovascular Diseases at the University of Extremo Sul Catarinense. To the team members who assisted in all stages of the article.

Funding

This work was supported by development agencies: Coordination for the Improvement of Higher Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq).

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Authors and Affiliations

  1. Laboratory of Immunoparasitology, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubãrao, Santa Catarina, Brazil

    Khiany Mathias & Josiane Somariva Prophiro

  2. Laboratory of Experimental Neurology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, Santa Catarina, Brazil

    Khiany Mathias, Richard Simon Machado, Solange Stork, Carla Damasio Martins, Amanda Christine da Silva Kursancew, Victória Linden de Rezende, Cinara Ludvig Gonçalves, Tatiana Barichello & Fabricia Petronilho

  3. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubãrao, Santa Catarina, Brazil

    Richard Simon Machado

  4. Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, 77054, USA

    Tatiana Barichello

  5. Laboratory of Experimental Neurology, University of Extremo Sul Catarinense, Criciuma, SC, Brazil

    Fabricia Petronilho

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Contributions

All authors contributed to the design of the article. KM and RSM: conceptualization; data curation; formal analysis; investigation; visualization; writing—original draft; writing—review and editing; conceptualization and writing. FP: data curation; formal analysis; writing—original draft; writing; supervision. All other authors commented on earlier versions of the manuscript. All authors have read and approved the final manuscript.

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Correspondence to Fabricia Petronilho.

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Mathias, K., Machado, R.S., Stork, S. et al. Bacillus Calmette-Guérin (BCG)-Induced Protection in Brain Disorders. Inflammation (2024). https://doi.org/10.1007/s10753-024-02018-1

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