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SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing NR4A1 Expression During Carotid Atherosclerosis

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Abstract

Macrophage-derived lipid-laden foam cells from the subendothelium play a crucial role in the initiation and progression of atherosclerosis. However, the molecule mechanism that regulates the formation of foam cells is not completely understood. Here, we found that SLAMF7 was upregulated in mice bone marrow–derived macrophages and RAW264.7 cells stimulated with oxidized low-density lipoprotein (ox-LDL). SLAMF7 promoted ox-LDL-mediated macrophage lipid accumulation and M1-type polarization. SLAMF7 deficiency reduced serum lipid levels and improved the lesions area of carotid plaque and aortic arch in high-fat diet-fed ApoE−/− mice. In response to ox-LDL, SLAMF7 downregulated NR4A1 and upregulated RUNX3 through transcriptome sequencing analysis. Overexpression NR4A1 reversed SLAMF7-induced lipid uptake and M1 polarization via inhibiting RUNX3 expression. Furthermore, RUNX3 enhanced foam cell formation and M1-type polarization. Taken together, the study suggested that SLAMF7 play contributing roles in the pro-atherogenic effects by regulating NR4A1-RUNX3.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by the Natural Science Foundation of Shandong Province (ZR2020MH139) and Shandong Province Postdoctoral Innovation Project (2021151).

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  1. Fengjiao Yuan and Jianmei Wei contributed equally to this work.

Authors and Affiliations

  1. Joint Laboratory for Translational Medicine Research, Liaocheng People’s Hospital, Liaocheng, Shandong, 252000, People’s Republic of China

    Fengjiao Yuan, Jianmei Wei, Yan Cheng, Feifei Wang & Mingliang Gu

  2. Department of Neurology, Liaocheng People’s Hospital, Shandong University, Jinan, Shandong, 250012, People’s Republic of China

    Fengjiao Yuan & Zhangyong Xia

  3. Medical Integration and Practice Center, Shandong University, Jinan, Shandong, 250012, People’s Republic of China

    Fengjiao Yuan

  4. Department of Rehabilitation Medicine, Liaocheng Chinese Medicine Hospital, Liaocheng, Shandong, 252000, People’s Republic of China

    Yanhui Li

  5. Department of Neurology, Liaocheng People’s Hospital and Liaocheng Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, 252000, People’s Republic of China

    Xin Zhao, Hao Sun, Ru Ban & Zhangyong Xia

  6. Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250014, People’s Republic of China

    Jing Zhou

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Contributions

Fengjiao Yuan and Jianmei Wei designed study, performed research, analyzed data, and wrote the paper. Yan Cheng and Feifei Wang performed research. Mingliang Gu and Yanhui Li guided experimental techniques. Xin Zhao, Hao Song, and Ru Ban interpreted pathology. Jing Zhou and Zhangyong Xia designed study, and revised the article. All authors read and approved the final manuscript.

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Correspondence to Jing Zhou or Zhangyong Xia.

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This study was performed in line with the principles of the Declaration of Helsinki. Animal experiment was conducted according to the Institutional Animal Care and Use Committee of the Model Animal Research Center. Approval was granted by the Ethics Committee of Liaocheng People’s Hospital.

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Yuan, F., Wei, J., Cheng, Y. et al. SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing NR4A1 Expression During Carotid Atherosclerosis. Inflammation 47, 530–542 (2024). https://doi.org/10.1007/s10753-023-01926-y

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