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Orthohantavirus Infection in Two Rodent Species that Inhabit Wetlands in Argentina

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Abstract

Previous research conducted in central-east region of Argentina recorded potential orthohantavirus host rodents in diverse environments, but no research has focused particularly on islands, the environments that present the greatest risk to humans. For this reason, the aims of this research were to determine the orthohantavirus host in the rodent community focused on islands of Paraná River Delta, central-east region of Argentina, to identify temporal and spatial factors associated with orthohantavirus prevalence variations, to compare the functional traits of seropositive and seronegative rodents, and to explore the association between orthohantavirus prevalence and rodent community characteristics between August 2014 and May 2018. With a trapping effort of 14,600 trap-nights, a total of 348 sigmodontine rodent specimens belonging to seven species were captured 361 times. The overall antibody prevalence was 4.9%. Particularly, 14.9% of Oligoryzomys flavescens and 1.5% of Oxymycterus rufus, mainly reproductively active adult males, had antibodies against orthohantavirus. Even though O. flavescens inhabit all islands, our results suggest spatial heterogeneity in the viral distribution, with two months after periods of low temperature presenting increases in seroprevalence. This could be a response to the increased proportion of adults present in the rodent population. In addition, an association was found between the high seroprevalence and the diversity of the rodent assemblage. We also found 1.5% of O. rufus exposed to orthohantavirus, which shows us that further investigation of the ecology of the virus is needed to answer whether this species act as a spillover or a new competent host.

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Acknowledgements

We are thankful to CONICET and Universidad de Buenos Aires for financial support for this study; to Administración de Parques Nacionales for their research authorizations to work in Pre-Delta and Islas de Santa Fe National Parks and their logistic support; to Entre Ríos and Santa Fe provinces for extending research authorizations. We also thank Eliana Burgos and Belén Crosignani for providing their help during the fieldwork.

Funding

Funding was provided by Universidad de Buenos Aires and Consejo Nacional de Investigaciones Científicas y Técnicas.

Author information

Authors and Affiliations

  1. Facultad de Ciencia y Tecnología, Universidad Autónoma de Entre Ríos, 3105, Diamante, Entre Ríos, Argentina

    Malena Maroli

  2. Instituto Nacional de Enfermedades Infecciosas Administración Nacional de Laboratorios e Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina

    Carla M. Bellomo, Rocío M. Coelho & Valeria P. Martinez

  3. Centro de Investigación Científica y de Transferencia Tecnológica a la Producción—Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencia y Tecnología, Universidad Autónoma de Entre Ríos, 3105, Diamante, Entre Ríos, Argentina

    Carlos I. Piña

  4. Instituto de Ecología, Facultad de Ciencias Exactas y Naturales, Genética y Evolución de Buenos Aires (CONICET-UBA), Universidad de Buenos Aires, Intendente Güiraldes 2160, Ciudad Universitaria, C1428EGA, Ciudad Autónoma de Buenos Aires, Argentina

    Isabel E. Gómez Villafañe

Authors
  1. Malena Maroli
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  2. Carla M. Bellomo
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  3. Rocío M. Coelho
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  4. Valeria P. Martinez
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  5. Carlos I. Piña
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  6. Isabel E. Gómez Villafañe
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Corresponding author

Correspondence to Isabel E. Gómez Villafañe.

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Maroli, M., Bellomo, C.M., Coelho, R.M. et al. Orthohantavirus Infection in Two Rodent Species that Inhabit Wetlands in Argentina. EcoHealth 20, 402–415 (2023). https://doi.org/10.1007/s10393-023-01661-8

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