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RETRACTED ARTICLE: Long non-coding RNA PICSAR serves as a non-invasive biomarker for the diagnosis and prognosis of cutaneous squamous cell carcinoma

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This article was retracted on 24 October 2023

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Abstract

Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignant tumors in dermatology, and its incidence is increasing year by year. Long non-coding RNAs (lncRNAs) play vital roles in the processes of various malignant tumors. This study aimed to evaluate the expression of long non-coding RNA PICSAR and investigate whether serum PICSAR could serve as a biomarker for the diagnosis and prognosis of cSCC. The expression level of PICSAR was measured using quantitative Real-Time PCR. The diagnostic value of PICSAR was evaluated by receiver operating characteristic (ROC) analysis. Survival curves were established using the Kaplan–Meier method, and the log-rank test was used to compare differences between the two curves. Prognostic value of PICSAR was confirmed by Cox regression analysis. The expression of PICSAR was upregulated in serum of cSCC patients and tumor tissues of patients. Additionally, serum PICSAR expression had relatively high diagnostic accuracy for the screening of cSCC. Moreover, PICSAR expression was correlated with tumor size, grade of differentiation and TNM stages, and significantly increased in cSCC patients with poor tumor differentiation and cSCC patients with III–IV TNM stage. Furthermore, patients with high PICSAR expression had lower overall survival than the patients with low PICSAR expression, and PICSAR expression was an independent prognostic factors for cSCC patients. The results of this study indicated that PICSAR was upregulated in cSCC patients and tumor tissues and might serve as a non-invasive biomarker for the diagnosis and prognosis of cSCC patients.

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Availability of data and material

The data used to support the findings of this study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Aesthetic Orthopaedics, Weifang People’s Hospital, No. 151, Guangwen Street, Kuiwen District, Weifang, 261041, Shandong, China

    Jianping Lv, Wei Zhang & Yanhua Wang

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  1. Jianping Lv
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  2. Wei Zhang
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Contributions

JL, WZ and YW analyzed and interpreted the data regarding, JL and WZ performed the examination of cell, JL and YW wrote the manuscript, JL, WZ and YW revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yanhua Wang.

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The authors declared that they have no conflict of interest.

Ethical approval

The experimental procedures were all in accordance with the guideline of the Ethics Committee of Weifang People’s Hospital and has been approved by the Ethics Committee of Weifang People's Hospital.

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A signed written informed consent was obtained from each patient.

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Written informed consent for publication was obtained from each participant.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s10238-023-01219-6

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Lv, J., Zhang, W. & Wang, Y. RETRACTED ARTICLE: Long non-coding RNA PICSAR serves as a non-invasive biomarker for the diagnosis and prognosis of cutaneous squamous cell carcinoma. Clin Exp Med 21, 579–586 (2021). https://doi.org/10.1007/s10238-021-00721-z

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  • DOI: https://doi.org/10.1007/s10238-021-00721-z

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