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Current Advances in Adeno-Associated Virus-Mediated Gene Therapy to Prevent Acquired Hearing Loss

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Abstract

Adeno-associated viruses (AAVs) are viral vectors that offer an excellent platform for gene therapy due to their safety profile, persistent gene expression in non-dividing cells, target cell specificity, lack of pathogenicity, and low immunogenicity. Recently, gene therapy for genetic hearing loss with AAV transduction has shown promise in animal models. However, AAV transduction for gene silencing or expression to prevent or manage acquired hearing loss is limited. This review provides an overview of AAV as a leading gene delivery vector for treating genetic hearing loss in animal models. We highlight the advantages and shortcomings of AAV for investigating the mechanisms and preventing acquired hearing loss. We predict that AAV-mediated gene manipulation will be able to prevent acquired hearing loss.

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Acknowledgements

We thank Dr. Jochen Schacht for his valuable comments on the manuscript, and we thank Andra Talaska for proofreading the manuscript.

Funding

R01 DC009222, from the National Institute on Deafness and Other Communication Disorders, National Institutes of Health, supports Dr. Sha’s research project.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Walton Research Building, Room 403-E, 39 Sabin Street, Charleston, SC, 29425, USA

    Fan Wu & Suhua Sha

  2. Department of Otolaryngology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

    Fan Wu

  3. Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425, USA

    Kumar Sambamurti

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  1. Fan Wu
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Correspondence to Suhua Sha.

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Wu, F., Sambamurti, K. & Sha, S. Current Advances in Adeno-Associated Virus-Mediated Gene Therapy to Prevent Acquired Hearing Loss. JARO 23, 569–578 (2022). https://doi.org/10.1007/s10162-022-00866-y

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