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Osteocompatibility of Si3N4-coated carbon fiber-reinforced polyetheretherketone (CFRP) and hydroxyapatite-coated CFRP with antibiotics and antithrombotic drugs

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  • Artificial Skin, Muscle, Bone / Joint, Neuron
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Abstract

This study used a rabbit model to investigate the osteocompatibility of Si3N4-coated carbon fiber-reinforced polyetheretherketone (CFRP) and hydroxyapatite (HA)-coated CFRP with antibiotics (vancomycin [VCM]) and antithrombotic drugs (polyvinylpyrrolidone [PVP]). HA-coated cylindrical CFRP implants were used as the controls (HA), and HA-coated implants treated with VCM and PVP were prepared (HA-VP) as the test groups; a cylindrical CFRP coated with Si3N4 was also prepared (SiN). Ten implants from each group were randomly inserted into the femoral diaphysis of rabbits. The pull-out test, radiological analysis using micro-computed tomography (µ-CT), and histological analysis were performed. The pull-out strength of the SiN group was lower than that of the HA group. µ-CT analysis revealed that the amount of bone formation around the implant in the SiN group was inferior to that in the HA group. Conversely, the HA-VP group had equivalent pull-out strength and bone formation as analyzed by µ-CT compared to the HA group. In conclusion, the additional surface treatment of the HA-coated CFRP with VCM and PVP provided sufficient bone fixation and formation.

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Acknowledgements

We would like to thank Professor Yasuhiko Tabata of Kyoto University for his advice on this research project.

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Author notes

  1. All authors equally contributed to this study.

Authors and Affiliations

  1. Department of Orthopaedic Medical Engineering, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Hideaki Enami, Wataru Ando & Nobuhiko Sugano

  2. Department of Orthopaedic Surgery, National Hospital Organization Osaka Minami Medical Center, 2-1 Kidohigashimachi, Kawachinagano, Osaka, 586-8521, Japan

    Ichiro Nakahara

  3. Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Keisuke Uemura, Hidetoshi Hamada & Masaki Takao

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  1. Hideaki Enami
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  2. Ichiro Nakahara
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  3. Wataru Ando
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  4. Keisuke Uemura
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  5. Hidetoshi Hamada
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  7. Nobuhiko Sugano
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Correspondence to Hideaki Enami or Nobuhiko Sugano.

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Enami, H., Nakahara, I., Ando, W. et al. Osteocompatibility of Si3N4-coated carbon fiber-reinforced polyetheretherketone (CFRP) and hydroxyapatite-coated CFRP with antibiotics and antithrombotic drugs. J Artif Organs 26, 144–150 (2023). https://doi.org/10.1007/s10047-022-01340-5

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  • DOI: https://doi.org/10.1007/s10047-022-01340-5

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