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Construction of a prognostic model for autophagy in Wilm's tumor

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Abstract

Background

Wilm's tumor (WT) is one of the most common childhood urological tumors, ranking second in the incidence of pediatric abdominal tumors. The development of WT is associated with various factors, and the correlation with autophagy is currently unclear.

Purpose

To develop a new prognostic model of autophagy-related genes (ATG) for WT.

Methods

Using the Therapeutically applicable research to generate effective treatments (TARGET) database to screen for differentially expressed ATGs in WT and normal tissues. ATGs were screened for prognostic relevance to WT using one-way and multifactorial Cox regression analyses and prognostic models were constructed. The risk score was calculated according to the model, and the predictive ability of the constructed model was analyzed using the ROC (receiver operating characteristic) curve to verify the significance of the model for the prognosis of WT.

Results

Sixty-eight differentially expressed ATGs were identified by univariate Cox regression analysis, and two critical prognostic ATGs (CXCR4 and ERBB2) were identified by multivariate Cox regression analysis. Patients were divided into high-risk and low-risk groups according to the differential expression of these two ATGs. Kaplan–Meier (KM) curves showed a significant difference in survival time between the two groups. The critical prognostic ATGs were combined with race, age, and stage in a multifactorial regression analysis, and the final prognostic model was produced as a line graph.

Conclusion

The prognostic model of autophagy-related genes composed of the CXCR4 gene and ERBB2 gene has a specific predictive value for the prognosis of WT, and the present study provides a clear basis for future research on biomarkers and therapeutic targets.

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Data availability

No datasets were generated or analysed during the current study.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Affiliated Matern and Child Care Hospital of Nantong University, 399 Century Avenue, Chongchuan, Nantong, Jiangsu, China

    Haoyu Shi, Min Zhang & Youbo Zhang

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  1. Haoyu Shi
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  2. Min Zhang
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Contributions

HYS: Designed the study; analyzed the data; drafted the initial manuscript; and reviewed and revised the manuscript. MZ: Designed the study; reviewed and revised the manuscript; critically revised the manuscript YBZ: reviewed and revised the manuscript; critically revised the manuscript All authors approved the final manuscript as submitted and agree to be accountable for all aspects of work.

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Correspondence to Min Zhang.

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Shi, H., Zhang, M. & Zhang, Y. Construction of a prognostic model for autophagy in Wilm's tumor. Pediatr Surg Int 40, 122 (2024). https://doi.org/10.1007/s00383-024-05712-1

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