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Clonal hematopoiesis and vascular disease

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Abstract

Somatic mutations in hematopoietic stem cells are common with aging and can result in expansion of clones harboring mutations, termed clonal hematopoiesis. This results in an increased risk of blood cancers but has also been linked with chronic inflammatory disease states. In recent years, clonal hematopoiesis has been established to have a causative role in atherogenesis and cardiovascular disease. Additionally, as the effector cells have been identified to be immune cells, there is ongoing interest in assessing whether dysregulated immune function plays a role in other chronic inflammatory conditions such as rheumatologic disease. Here, we summarize current understanding of clonal hematopoiesis with a focus on cardiovascular disease and inflammation while outlining the potential, yet unexplored, relationship between clonal hematopoiesis and autoimmune disease.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    Kaushik Amancherla & John A. Wells IV

  2. Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA

    Alexander G. Bick

Authors
  1. Kaushik Amancherla
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  2. John A. Wells IV
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  3. Alexander G. Bick
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Correspondence to Alexander G. Bick.

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Conflict of interest

Dr. Amancherla serves on an adjudication committee for ACI Clinical. Dr. Bick is on the scientific advisory board of TenSixteen Bio.

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This article is a contribution to the special issue on: Inflammation in vascular diseases - Guest Editors: Mariana Kaplan & Peter Grayson

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Amancherla, K., Wells, J.A. & Bick, A.G. Clonal hematopoiesis and vascular disease. Semin Immunopathol 44, 303–308 (2022). https://doi.org/10.1007/s00281-022-00913-z

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  • DOI: https://doi.org/10.1007/s00281-022-00913-z

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