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Elevated serum IL-6 and total IgEAb are associated with poor survival in natural killer/T-cell lymphoma

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Abstract

Natural killer/T‐cell lymphoma (NKTCL) is an aggressive and malignant condition with a high mortality rate. Prognostic factors may assist to evaluate the outcome of the disease and may also be useful in selecting appropriate therapeutic strategies for patients. The study aims to describe NKTCL in terms of its clinical features, laboratory examinations, and immunophenotypes and to analyze relevance affecting patient survival outcomes. The patients diagnosed as NKTCL in Jinling Hospital from Jan. 2012 to Dec. 2022 were reviewed retrospectively in this study basing on histopathology. The analysis was performed to evaluate overall survival (OS). A total of 125 NKTCL patients were included, which mainly affected male more than female with the onset median age of 51.00 years old (range, 14 ~ 85 y). NKTCL commonly affects the nasopharynx and upper aerodigestive tract, intestines, and skin. The median overall survival was 13.00 months (range, 2–156 m), and the 5-year survival rate was 9.8%. Under univariable analysis revealed the following factors at diagnosis age: serum total IgEAb ≥ 54.6 IU/mL, IL-6 ≥ 32.445 ng/L, elevated PINK score, smoking, and extranasopharyngeal site were statistically significant predictors for OS. Compared to the patients who received radiotherapy alone or chemotherapy alone, the patients who received combined chemoradiotherapy had longer OS. We found that IL-6 and total IgEAb were significant prognostic factors in NKTCL patients. Also, extranasopharyngeal site was correlated with advanced disease.

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The data underlying this article will be shared on reasonable request to the corresponding authors.

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Funding

This work was supported by the Jiangsu Dermatology Innovation Team Foundation (grant number CXTDA2017038).

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Author notes

  1. Yun Hui and Yingjun Gao contributed equally to this work.

Authors and Affiliations

  1. Department of Dermatology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China

    Yun Hui, Qingtao Kong, Haibo Liu & Fang Liu

  2. Department of Dermatology, Jinling Hospital, Nanjing Medical University, Nanjing, China

    Yingjun Gao & Hong Sang

  3. School of Medicine, Southeast University, Nanjing, China

    Jiawei Li

  4. Department of Allergy and Rheumatology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China

    Yuanyuan Duan

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  1. Yun Hui
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  2. Yingjun Gao
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  4. Qingtao Kong
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  6. Haibo Liu
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  7. Fang Liu
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  8. Hong Sang
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Contributions

All authors contributed to the study’s conception and design. FL, HL, and YD designed the study. YH and YG collected and analyzed the data. FL, YH, and YG prepared the manuscript. HS revised the manuscript. All authors approved the final manuscript, took responsibility for the content, and agreed to submit it for publication.

Corresponding authors

Correspondence to Yuanyuan Duan, Haibo Liu or Fang Liu.

Ethics declarations

Ethics approval

This study was approved by the Ethics Committee of the Jinling Hospital of Nanjing University (approval number 2023DZGZR-055) and was conducted according to the principles of the Helsinki Declaration.

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Individual consent was not necessary because the study used existing clinical data and the identity of the patients was not disclosed.

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The authors declare no competing interests.

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Hui, Y., Gao, Y., Li, J. et al. Elevated serum IL-6 and total IgEAb are associated with poor survival in natural killer/T-cell lymphoma. Ann Hematol 103, 1285–1292 (2024). https://doi.org/10.1007/s00277-023-05579-7

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  • DOI: https://doi.org/10.1007/s00277-023-05579-7

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