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Effect of platelet-rich plasma versus triamcinolone acetonide as adjuvant therapy to surgical excision of keloid

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European Journal of Plastic Surgery Aims and scope Submit manuscript

Abstract

Background

Keloids are a cause of functional and aesthetic disfigurement. There are multiple treatment modalities. In this study, we did a comparison between the effect of platelet-rich plasma (PRP) and triamcinolone acetonide as an adjuvant to surgical excision of keloid. We aimed to compare the effect of PRP versus triamcinolone acetonide after surgical excision of the keloids in a group of randomized patients in terms of clinical improvement, recurrence, and patient satisfaction.

Methods

Between April 2019 to November 2020, we divided a total of 30 patients into two groups in whom surgical excision and closure of keloid were done, followed by injection of PRP (group A) and injection triamcinolone acetonide (group B) as adjuvant into the wound bed intraoperatively and then monthly for 3 months. They were followed up for a period of 6 months, and scar quality, patient satisfaction, and recurrence of keloid were analysed.

Results

Significant improvement was seen in the vancouver scar scale (VSS) in all patients. The mean preoperative VSS of group A and group B patients was similar [7.87 ± 1.60 and 7.47 ± 1.36, respectively (p = 0.633)]. The mean postoperative VSS at the end of 6 months in group A and group B patients was 3.20 ± 1.93 and 1.80 ± 1.08, respectively (p = 0.031). Hence, the improvement in scar quality was better in group B. The recurrence of keloid was less in group B patients (p = 0.031).

Conclusions

Injection Triamcinolone acetonide as an adjuvant following surgical excision of keloids gives better scar quality as compared to the injection PRP with lesser recurrence.

Level of evidence: Level II, therapeutic study.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Post Graduate Department of Plastic Surgery, King Georges Medical College, Shahmeena Road, Lucknow, UP, 226003, India

    Neelam Chauhan, Vijay Kumar, Brijesh Mishra, Divya Narayan Upadhyaya & Arun Kumar Singh

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  1. Neelam Chauhan
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  2. Vijay Kumar
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  3. Brijesh Mishra
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  4. Divya Narayan Upadhyaya
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  5. Arun Kumar Singh
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Corresponding author

Correspondence to Neelam Chauhan.

Ethics declarations

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki.

Approval was granted by the Ethics Committee of King Georges Medical University (Date 22/05/2019

No.711/Ethics/19).

Consent to participate

Informed consent was obtained from all individual participants included in the study and from parents in the case of minors.

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The authors affirm that human research participants provided informed consent for the publication of the images in Figs. 3 and 4.

Competing interests

Neelam Chauhan, Vijay Kumar, Brijesh Mishra, Divya Narayan Upadhyaya, and Arun Kumar Singh declare no competing interests.

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Chauhan, N., Kumar, V., Mishra, B. et al. Effect of platelet-rich plasma versus triamcinolone acetonide as adjuvant therapy to surgical excision of keloid. Eur J Plast Surg 46, 733–739 (2023). https://doi.org/10.1007/s00238-023-02070-4

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  • DOI: https://doi.org/10.1007/s00238-023-02070-4

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