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Effectiveness of paracetamol-NSAID combinations for upper and lower respiratory tract infections: a preliminary evaluation in primary care

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References

  1. Thybo KH, Hägi-Pedersen D, Wetterslev J et al (2017) PANSAID - PAracetamol and NSAID in combination: study protocol for a randomised trial. Trials. https://doi.org/10.1186/s13063-016-1749-7

    Article  PubMed  PubMed Central  Google Scholar 

  2. Bailey E, Worthington HV, van Wijk A et al (2013) Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD004624.pub2

    Article  PubMed  Google Scholar 

  3. Moore PA, Hersh EV (2013) Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice. J Am Dent Assoc 144:898–908. https://doi.org/10.14219/jada.archive.2013.0207

    Article  CAS  PubMed  Google Scholar 

  4. Lauder SN, Taylor PR, Clark SR et al (2011) Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66:368–374. https://doi.org/10.1136/thx.2010.150318

    Article  PubMed  Google Scholar 

  5. Leal NS, Yu Y, Chen Y et al (2021) Paracetamol is associated with a lower risk of COVID-19 infection and decreased ACE2 Protein expression: a retrospective analysis. COVID 2021 1:218–229. https://doi.org/10.3390/COVID1010018

  6. Sokolowska M, Rovati GE, Diamant Z et al (2022) Effects of non-steroidal anti-inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID-19. Allergy 77:2337–2354. https://doi.org/10.1111/ALL.15258

    Article  CAS  PubMed  Google Scholar 

  7. Nainu F, Mamada SS, Emran TB (2023) Prospective role of NSAIDs with antiviral properties for pharmacological management of postsurgical procedures during COVID-19. Int J Surg 109:109. https://doi.org/10.1097/JS9.0000000000000101

    Article  PubMed  PubMed Central  Google Scholar 

  8. Lapi F, Marconi E, Grattagliano I et al (2022) To clarify the safety profile of paracetamol for home-care patients with COVID-19: a real-world cohort study, with nested case–control analysis, in primary care. Intern Emerg Med 17:2237–2244. https://doi.org/10.1007/s11739-022-03054-1

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lapi F, Marconi E, Grattagliano I, Cricelli C (2023) Further data on use of NSAIDs for the home-care therapy of COVID-19. 18:1599–1602. https://doi.org/10.1007/s11739-023-03272-1

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Funding

The study was funded by an unconditional grant from Angelini Pharma.

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Authors and Affiliations

Authors

Contributions

FL, and EM have made substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data. FL, EM, PLA, AR, DF and CC have been involved in drafting the manuscript or revising it critically for important intellectual content. Each author should have participated sufficiently in the work to take public responsibility for appropriate portions of the content. FL agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Corresponding author

Correspondence to Francesco Lapi.

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Competing interests

FL and EM provided consultancies in protocol preparation for epidemiological studies and data analyses for Angelini, Dompè, GSK and Viatris. PLA, AR and CC provided clinical consultancies for Angelini, Dompè, GSK and Viatris. The other authors have no conflicts of interest to disclose.

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The funder had no role in the design and execution of this study as well as in analyses, interpretation of the data, and manuscript submission.

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Lapi, F., Marconi, E., Aprile, P.L. et al. Effectiveness of paracetamol-NSAID combinations for upper and lower respiratory tract infections: a preliminary evaluation in primary care. Eur J Clin Pharmacol 80, 781–783 (2024). https://doi.org/10.1007/s00228-024-03651-3

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  • DOI: https://doi.org/10.1007/s00228-024-03651-3

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