Vaccine Adjuvants

1. Front Matter

   Pages i-xi

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2. Microbial Pathogenesis and the Discovery of Toll-Like Receptor Function

   • Bruce Beutler

   Pages 1-24

3. Dendritic Cells

   • Bali Pulendran, Anshu Agrawal, Stephanie Dillon, Sudhanshu Agrawal

   Pages 25-38

4. Achieving Transcriptional Specificity in NF-κB-Dependent Inflammatory Gene Expression

   • Gioacchino Natoli

   Pages 39-48

5. Adjuvants and the Initiation of T-Cell Responses

   • Matthew F. Mescher, Julie M. Curtsinger, Marc Jenkins

   Pages 49-67

6. Mechanism for Recognition of CpG DNA

   • Kiyoshi Takeda, Hiroaki Hemmi, Shizuo Akira

   Pages 69-86

7. CpG ODN As a Th1 Immune Enhancer for Prophylactic and Therapeutic Vaccines

   • Arthur M. Krieg, Heather L. Davis

   Pages 87-110

8. Modified Bacterial Toxins

   • Ed C. Lavelle, Olive Leavy, Kingston H. G. Mills

   Pages 111-153

9. Glycosylphosphatidylinositol Anchors As Natural Immunological Adjuvants Derived From Protozoan Parasites

   • Ricardo T. Gazzinelli, Catherine Ropert, Igor C. Almeida, João S. Silva, Marco A. Campos

   Pages 155-175

10. The Immunomodulatory Glycan LNFPIII/Lewis X Functions As a Potent Adjuvant for Protein Antigens

    • Mitsuhiro Okano, Kazunori Nishizaki, Akram Da’dara, Paul Thomas, Michele Carter, Donald A. Harn Jr.

    Pages 177-191

11. Immune and Antiviral Effects of the Synthetic Immunomodulator Murabutide

    • George M. Bahr

    Pages 193-219

12. Effects of QS-21 on Innate and Adaptive Immune Responses

    • Charlotte Read Kensil, Gui Liu, Christine Anderson, James Storey

    Pages 221-234

13. Monophosphoryl Lipid A and Synthetic Lipid A Mimetics As TLR4-Based Adjuvants and Immunomodulators

    • Jory Baldridge, Kent Myers, David Johnson, David Persing, Christopher Cluff, Robert Hershberg

    Pages 235-255

14. Microparticles and DNA Vaccines

    • Kimberly Denis-Mize, Manmohan Singh, Derek T. O’Hagan, Jeffrey B. Ulmer, John J. Donnelly

    Pages 257-270

15. Back Matter

    Pages 271-284

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A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.

• Antigen
• bacteria
• genes
• lipide
• parasite
• parasites
• pathogenesis
• protein
• research
• vaccine

From the reviews:

"This book describes in detail major advances in vaccine adjuvant discovery, design, development, and use. … fills a void in our knowledge of vaccine adjuvants, providing one authoritative text source for the latest information on this topic. The book meets the authors’ objectives superbly. … it could serve as a reference for students, residents, and practitioners, particularly in the fields of infectious diseases and immunology. … It will serve as a valuable reference for those interested in this field." (Archana NMI Chatterjee, Doody’s Review Service, July, 2006)

• Division of Allergy, Immunology, and Transplantation National Institute of Allergy and Infectious Diseases, NIH, Bethesda

  Charles J. Hackett

• Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston

  Donald A. Harn

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